Jiakai Han1, Wei Gao1, Dongyue Su, Yang Liu
Oncology Research, Vol.25, No.6, pp. 873-878, 2017, DOI:10.3727/096504016X14783701102564
Abstract A-kinase anchor protein 4 (AKAP4), a member of the A-kinase anchor family of proteins, plays a role in tumor
development and progression. However, its expression pattern and function in human thyroid cancer remain
obscure. Here we examined AKAP4 expression in thyroid cancer cell lines as well as the effects of AKAP4
on the proliferation and metastasis of thyroid cancer cells. We also explored the molecular mechanism by
which AKAP4 mediates the metastatic potential of thyroid cancer cells. Our results revealed that the transcript
and protein levels of AKAP4 were significantly upregulated in thyroid cancer cell… More >
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