Sofija Jovanović Stojanov1, Marija Grozdanić1, Mila Ljujić2, Sandra Dragičević2, Miodrag Dragoj1, Jelena Dinić1,*
Oncology Research, Vol.33, No.10, pp. 2741-2785, 2025, DOI:10.32604/or.2025.067126
- 26 September 2025
Abstract Anticancer drug resistance remains a major challenge in cancer treatment hindering the efficacy of chemotherapy and targeted therapies. Conventional two-dimensional (2D) cell cultures cannot replicate the complexity of the in vivo tumor microenvironment (TME), limiting their utility for drug resistance research. Therefore, three-dimensional (3D) tumor models have proven to be a promising alternative for investigating chemoresistance mechanisms. In this review, various cancer 3D models, including spheroids, organoids, scaffold-based models, and bioprinted models, are comprehensively evaluated with a focus on their application in drug resistance studies. We discuss the materials, properties, and advantages of each model, highlighting More >
Graphic Abstract