Jeong Yong Jeon*1, Misu Lee*†1, Sang Hyun Whang*, Jung-Whan Kim‡, Arthur Cho*, Mijin Yun*
Oncology Research, Vol.26, No.1, pp. 71-81, 2018, DOI:10.3727/096504017X14902648894463
Abstract Altered energy metabolism is a biochemical fingerprint of cancer cells. Hepatocellular carcinoma (HCC)
shows reciprocal [18F]fluorodeoxyglucose (FDG) and [11C]acetate uptake, as revealed by positron emission
tomography/computed tomography (PET/CT). Previous studies have focused on the role of FDG uptake in
cancer cells. In this study, we evaluated the mechanism and roles of [11C]acetate uptake in human HCCs and
cell lines. The expression of monocarboxylate transporters (MCTs) was assessed to determine the transporters of [11C]acetate uptake in HCC cell lines and human HCCs with different [11C]acetate uptake. Using two
representative cell lines with widely different [11C]acetate uptake (HepG2 for high… More >
Login
Register
