DAOLUN YU1, DEYONG SHE2, KAI GE1, LEI YANG1, RUINA ZHAN1, SHAN LU3,*, YAFEI CAI4,*
BIOCELL, Vol.48, No.1, pp. 139-147, 2024, DOI:10.32604/biocell.2023.045884
- 30 January 2024
Abstract Background: SMAD family proteins (SMADs) are crucial transcription factors downstream of transforming growth factor beta (TGF-ß)/SMAD signaling pathways that have been reported to play a pivotal role in mammalian reproduction. However, the role of SMAD family member 8 (SMAD8, also known as SMAD9), a member of the SMAD family, in mammalian reproduction remains unclear. Methods: We employed RNA interference techniques to knock down Smad8 expression in mouse granulosa cells (GCs) to investigate the effects of Smad8 on GC growth and steroidogenesis. Results: Our findings revealed a significant decrease in the proliferative capacity and a substantial increase in… More >
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