Yasemin Baskin*†‡, Gizem Calibasi Kocal‡§, Betul Bolat Kucukzeybek¶, Mahdi Akbarpour#, Nurcin Kayacik**, Ozgul Sagol††, Hulya Ellidokuz†‡‡, Ilhan Oztop§§
Oncology Research, Vol.24, No.1, pp. 41-53, 2016, DOI:10.3727/096504016X14576297492418
Abstract Most of the gastrointestinal stromal tumors (GISTs) have gain-of-function mutations in the KIT gene, which
can be used as a prognostic marker for the biological behavior of tumors, predictive marker for the response of
tyrosine kinase inhibitors, and diagnostic marker. Researchers have focused on PDGFRA mutations because
of both their prognostic and predictive potential and DOG1 positivity for diagnosis on GISTs. The aim of
this study is to investigate the effect DOG1, PDGFRA, and KIT mutations on the prediction of the outcome
for GIST management. Polymerase chain reaction was performed for KIT gene exons 9, 11, 13,… More >
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