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    ARTICLE

    Novel mutation of GATA4 gene in Kurdish population of Iran with nonsyndromic congenital heart septals defects

    Fariborz Soheili1,2, Zahra Jalili3, Mahtab Rahbar4, Zahed Khatooni1, Amir Mashayekhi5, Hossein Jafari6

    Congenital Heart Disease, Vol.13, No.2, pp. 295-304, 2018, DOI:10.1111/chd.12571

    Abstract Background: The mutations in GATA4 gene induce inherited atrial and ventricular septation defects, which is the most frequent forms of congenital heart defects (CHDs) constituting about half of all cases.
    Method: We have performed High resolution melting (HRM) mutation scanning of GATA4 coding exons of nonsyndrome 100 patients as a case group including 39 atrial septal defects (ASD), 57 ventricular septal defects (VSD) and four patients with both above defects and 50 healthy individuals as a control group. Our samples are categorized according to their HRM graph. The genome sequencing has been done for 15 control samples and… More >

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