KERAN JIA1, YANHAO ZHANG1, MENGYU JIANG2, MENGGE CUI2, JIA WANG2, JIAJIA ZHANG2, HUIHAI ZHAO2, MENGYAN LI2, HUA WANG2, QUANMING ZOU1,#,*, HAO ZENG1,#,*
BIOCELL, Vol.48, No.9, pp. 1355-1368, 2024, DOI:10.32604/biocell.2024.051383
- 04 September 2024
Abstract Objective: Candida albicans is a common fungal pathogen that triggers complex host defense mechanisms,
including coordinated innate and adaptive immune responses, to neutralize invading fungi effectively. Exploring the
immune microenvironment has the potential to inform the development of therapeutic strategies for fungal
infections. Methods: The study analyzed individual immune cell profiles in peripheral blood mononuclear cells from
Candida albicans-infected mice and healthy control mice using single-cell transcriptomics, fluorescence quantitative
PCR, and Western blotting. We investigated intergroup differences in the dynamics of immune cell subpopulation
infiltration, pathway enrichment, and differentiation during Candida albicans infection. Results: Our findings
indicate that infiltration… More >
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