HASSAN BAYDOUN1, YUJI KATO1, HIROKI KAMO1, ANNA HÜSCH1,2, HAYATO MIZUTA1, RYOTA KAWAHARA1, SIRO SIMIZU1,*
Oncology Research, Vol.32, No.4, pp. 607-614, 2024, DOI:10.32604/or.2023.030304
Abstract
C-mannosylation is a post-translational modification that occurs intracellularly in the endoplasmic reticulum. In humans, biosynthesis of C-mannosylation in proteins containing thrombospondin type 1 repeat is catalyzed by the DPY19 family; nonetheless, biological functions of protein C-mannosylation are not yet fully understood, especially in tumor progression. Vasculogenic mimicry (VM) is the formation of fluid-conducting channels by highly invasive and genetically deregulated tumor cells, enabling the tumors to form matrix-embedded vasculogenic structures, containing plasma and blood cells to meet the metabolic demands of rapidly growing tumors. In this study, we focused on DPY19L3, a C-mannosyltransferase, and aimed to unravel
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