Open Access

ARTICLE

Phytochemical and Pharmacological Study on the Dry Extract of Matricaria discoidea DC. herb and Its Amino Acids Preparations

Oleh Koshovyi^1,2,*, Janne Sepp¹, Valdas Jakštas³, Vaidotas Žvikas³, Karina Tolmacheva⁴, Igor Kireyev⁴, Jyrki Heinämäki¹, Ain Raal^1,*

1 Institute of Pharmacy, Faculty of Medicine, University of Tartu, Tartu, 50411, Estonia
2 Department of Pharmacognosy and Nutritionology, National University of Pharmacy, Kharkiv, 61002, Ukraine
3 Institute of Pharmaceutical Technologies, Lithuanian University of Health Sciences, Kaunas, 44307, Lithuania
4 Department of Clinical Pharmacology, Institute for Continuing Education of Pharmacy Professionals, National University of Pharmacy, Kharkiv, 61002, Ukraine

* Corresponding Authors: Oleh Koshovyi. Email: ; Ain Raal. Email:

Phyton-International Journal of Experimental Botany 2024, 93(11), 2909-2925. https://doi.org/10.32604/phyton.2024.056536

Received 24 July 2024; Accepted 17 October 2024; Issue published 30 November 2024

Abstract

Pineappleweed (Matricaria discoidea DC., Asteraceae) herb is an essential oil containing raw material with spasmolytic and anti-inflammatory activity. It is also rich in phenolics, which may be used in pharmaceutical practice. This study aimed to investigate the phenolic and amino acid composition and the hyporific and analgesic effects of the M. discoidea aqueous-ethanolic extract and its amino acid modifications. In addition, we developed a polyethylene oxide gel formulation with M. discoidea extracts for the 3D-printed oral solid dosage preparations. In M. discoidea extracts, 16 phenolic substances and 14 amino acids were established. The extract and its amino acid preparations revealed both analgesic and soporific activity in the studies with rodents. Amino acids enhanced these effects. Arginine, β-alanine, glycine, valine, and lysine potentiated the analgesic activity by 27%–64%, while β-alanine, glycine, and valine increased the soporific activity by 136%, 176%, and 129%, respectively. The composition of the polyethylene oxide (PEO) printing gel with the M. discoidea extract was developed, and its printability was confirmed. The proposed 3D-printed medicines could be implemented for sleep disorders and painful conditions.

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Keywords

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