Special Issue "Plant Secondary Metabolites: Recent Advances and Opportunities"

Submission Deadline: 31 December 2020 (closed)
Guest Editors
Prof. Ram Prasad, Sun Yat-Sen University,China
Dr. Joginder Singh, Lovely Professional University, India


Studies on plant secondary metabolites have been increasing over the last 50 years. These molecules are known to play a major role in the adaptation of plants to their environment, but also represent an important source of active pharmaceuticals. Plant cell culture technologies were introduced at the end of the 1960s as a possible tool for both studying and producing plant secondary metabolites. The main advantages of using plant cell and tissue culture techniques for the production of plant secondary metabolites are obtainable as well as the different biotechnological approaches available to improve their production of metabolites, including important alkaloids with anticancer properties and bioactive phenolics. Moreover, many secondary metabolites hold valuable effects on human health and are used as bioactive components of drugs. Plant secondary metabolites have been an abundant area of chemical investigation for many years, driving the development of both analytical chemistry and of new synthetic reactions and methodologies. The subject is multi-disciplinary with chemists, biochemists and plant scientists all contributing to our current understanding. In recent years there has been an improvement in interest from other disciplines, related to the realization that secondary metabolites are dietary components that may have a significant impression on human health, and to the development of gene technology that permits modulation of the contents of desirable and undesirable components.

This special issue is proposed to explore the most recent happenings and innovation occurs during recent years in the field of plant secondary metabolites. The manuscripts are being saught that address the following topics:
1) Plant derived secondary metabolites: Source, structures and biology;
2) Secondary metabolites biosynthesis from plants;
3) Microbial mediated enhances of Secondary metabolites of plants;
4) Physiological and molecular mechanisms for the production of secondary metabolites in plants;
5) Application of plant biotechnology for the effective production of secondary metabolites;
6) Transcriptomics approaches for large scale identification of genes involved in plant secondary metabolism;
7) Application of bioinformatics for production of plant secondary metabolites;
8) Technical obstacles in plant secondary metabolites production.

Secondary metabolites, active ingredients, plant cell culture, metabolic engineering

Published Papers
  • In vitro Antibacterial Activity of Moringa oleifera Ethanolic Extract against Tomato Phytopathogenic Bacteria
  • Abstract The tomato (Solanum lycopersicum L.) is one of the world’s most important vegetable crops. Still, phytopathogenic bacteria affect the yield and quality of tomato cultivation, like Agrobacterium tumefeciens (At), Clavibacter michiganensis subsp. michiganensis (Cmm), Pseudomonas syringae pv. tomato (Pst), Ralstonia solanacearum (Rs), and Xanthomonas axonopodis (Xa). Synthetic chemical products are used mostly on disease plant control, but overuse generates resistance to bacterial control. This study aimed to evaluate the in vitro antibacterial activity of the ethanolic extract of Moringa oleifera Lam. leaves against At, Cmm, Pst, Rs, and Xa, as well as information about this plant species’ chemical composition. Antibacterial… More
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  • Antifeedant Activity of Caesalpinia coriaria Essential Oil Against Incisitermes marginipennis (Latreille)
  • Abstract This study scrutinized the possibility of finding toxicant or deterrent plant metabolites against the dry wood termite Incisitermes marginipennis (Latreille). Plant deterrent agents act as repellents or antifeedants to prevent wood decay and increase its useful life. The potential of the tree Caesalpinia coriaria (Fabaceae) as a biological source of molecules with deterrent effects against the dry wood termite was assessed by a phytochemical fractionation guided by repellence and antifeedant activities. The gas chromatography-mass spectrometry analysis of the leaf essential oil showed geraniol to be one of the major components and its repellent and antifeedant effects were determined. Geraniol had… More
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  • Evaluation of Ocimum basilicum L. with Different Concentrations of K+ as an Inhibitor of Pathogenic Bacterial Strains
  • Abstract The extraction of bioactive compounds has become one of the most interesting areas of modern chemistry. For therapeutic reasons, it´s important to obtain antimicrobial agents from natural origin. The objective of the present study was to determine the inhibitory effect of ethanolic extract of basil (Ocimum basilicum L. var. Red Rubin) subjected to different concentrations of potassium (K+) on the activity of three bacterial strains that are pathogens in humans. Susceptibility was evaluated by inhibition surface and these results were compared to two antibiotics: Gentamicin (GE) and Ciprofloxacin (CPF) for their efficacy against each bacterial strain. Analyzed variables presented significant… More
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  • Establishment of Rhodiola quadrifida Hairy Roots and Callus Culture to Produce Bioactive Compounds
  • Abstract Rhodiola quadrifida is a rare mountain medicinal plant whose root extracts are used in traditional Chinese medicine as a hemostatic, antitussive, and tonic in the treatment of gynecological diseases. The aim of the study was to obtain R. quadrifida cultures at different degrees of differentiation in vitro and compare their growth characteristics and the content of salidroside and rosavin. Hairy roots were obtained by incubating cotyledons and hypocotyls in a suspension of Agrobacterium rhizogenes strain A4. The presence of the rolB and rolC genes was proven by polymerase chain reaction. The obtained roots were cultivated in Murashige-Skoog medium (MS). Calluses… More
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  • Anthocyanin Profiles in Grape Berry Skins of Different Species of Wine Grapes in Shanxi, China
  • Abstract To understand the anthocyanin characteristics of wine grape varieties, the anthocyanin composition and content of 31 wine grape varieties were analyzed to explore the use of anthocyanins as chemical fingerprints to distinguish varieties. Results showed that a total of 21 anthocyanins were detected in the skins, including cyanidin, delphinidin, petunidin, peonidin and malvidin 3-monoglucosides (or 3,5-diglucosides) along with the corresponding acetyl and p-coumaroyl derivatives. The highest and lowest total amount of anthocyanins were detected in ‘Ruby Cabernet’ and ‘Muscat Rouge’, respectively. In the 21 Vitis vinifera grapes, there were 3~11 monoglucoside anthocyanins detected, however, there were 4 to 9 monoglucoside… More
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  • Do Strigolactones Regulate Bud Winter Dormancy and Charactrisitc Secondary Metabolism in Tea?
  • Abstract Tea (Camellia sinensis [L.] O. Kuntze.) is an important cash crop, which mainly uses tender shoots and young leaves for manufacturing. Due to the marketing characteristic that earlier made tea has higher price, the time of the breaking of winter dormancy buds in spring is extremely important in tea industry. Strigolactones are a group of carotenoids-derived metabolites which regulates bud outgrowth, shoot branching, tiller angle and environmental stress responses. The role of strigolactones in tea plant was briefly summarized in the current review, with an emphasis of the association of strigolactones on bud ecodormancy and shoot branching. The involvement of… More
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  • Changes in Phyto-Chemical Status upon Viral Infections in Plant: A Critical Review
  • Abstract Most damaging plant diseases have been caused by viruses in the entire world. In tropical and subtropical areas, the damage caused by plant virus leads to great economic and agricultural losses. Single stranded DNA viruses (geminiviruses) are the most perilous pathogens which are responsible for major diseases in agronomic and horticultural crops. Significantly begomoviruses and mastreviruses are the biggest genus of plant infecting viruses, transmitted though Bemisia tabaci and members of Cicadellidae respectively. Plants possesses some naturally existing chemicals term as phyto-chemicals which perform important functions in the plant. Some antioxidant enzymes are used by plants for self-defense upon foreign… More
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  • Conservation Strategy for African Medicinal Species: In Vitro Biotechnological Approach
  • Abstract The use of medicinal plants for different therapeutic values is well documented in African continent. African diverse biodiversity hotspots provide a wide range of endemic species, which ensures a potential medicinal value. The feasible conservation approach and sustainable harvesting for the medicinal species remains a huge challenge. However, conservation approach through different biotechnological tools such as micropropagation, somatic embryogenesis, synthetic seed production, hairy root culture, molecular markers based study and cryopreservation of endemic African medicinal species is much crucial. In this review, an attempt has been made to provide different in vitro biotechnological approaches for the conservation of African medicinal… More
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  • Therapeutic Applications of Naringenin, a Flavanone Enriched in Citrus Fruits, for Disorders beyond Diabetes
  • Abstract In recent years, there has been an increase in epidemiological studies to highlight the health benefits of plant secondary metabolites. Flavonoids (polyphenolic plant secondary metabolites) are recently emerging as an important source for the discovery of new drugs increasing their pharmaceuticals, nutraceutical and medicinal applications. Naringenin is a flavanone, enriched in citrus fruits, tomatoes, bergamot, etc. which has been evaluated extensively for managing diabetes. However, in addition to this, naringenin had been ascribed to various important biological activities like antioxidant, antiviral, anticancer, anti-inflammatory, antiestrogenic, etc. This article aims at highlighting the therapeutic value of naringenin in managing disorders other than… More
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