Changing climatic conditions are major threats to sustainable agriculture. Increasing intensity of biotic (diseases, pests, and pathogens) and abiotic stresses (drought, salinity, sodicity, and heavy metals) are big hurdles for the achievement of maximum crop productivity. Scientists are working on different remediation technologies to encounter these biotic and abiotic stresses. The use of symbiotic i.e., the plant-microbes association is one such environment-friendly technology. An increase in nutrients and water uptake, root elongation, growth hormones secretions, precipitation and chelation of toxic ions are major characteristics of beneficial microbes which can enhance crop productivity under biotic and abiotic stresses. This Special Issue will help to cover the knowledge gaps of the nutrients management and symbiosis mechanism involved in the crop’s immunization and competition of symbiotic and pathogenic microorganisms under biotic and abiotic stresses. Therefore, we invite researchers to contribute to the Special Issue on “Symbiotic associations for Nutrients Management and Complexes formation for better Agricultural Crops Productivity under Biotic and Abiotic Stresses” which is intended to cover broad aspects of symbiosis for nutrients management on crops growth and productivity under abiotic stresses.