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ARTICLE

Phytochemical and Pharmacological Research in Galenic Remedies of Solidago canadensis L. Herb

Yurii Hrytsyk1, Oleh Koshovyi2,3, Martin Lepiku4, Valdas Jakštas5, Vaidotas Žvikas5, Tetiana Matus1, Mariia Melnyk1, Lyubov Grytsyk1, Ain Raal2,*
1 Department of Pharmaceutical Management, Drug Technology and Pharmacognosy, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, 61002, Ukraine
2 Institute of Pharmacy, Faculty of Medicine, University of Tartu, Tartu, 50411, Estonia
3 Department of Pharmacognosy and Nutriciology, National University of Pharmacy, Kharkiv, 61002, Ukraine
4 Institute of Chemistry, Faculty of Science and Technology, University of Tartu, Tartu, 50411, Estonia
5 Institute of Pharmaceutical Technologies, Lithuanian University of Health Sciences, Kaunas, 44307, Lithuania
* Corresponding Author: Ain Raal. Email: email

Phyton-International Journal of Experimental Botany https://doi.org/10.32604/phyton.2024.055117

Received 17 June 2024; Accepted 23 August 2024; Published online 11 September 2024

Abstract

Canadian goldenrod (Solidago canadensis L.) is a rhizomatous plant of the Asteraceae family. In folk medicine, Solidago galenic remedies are used for diseases of the kidneys, urinary tract, liver, etc. Externally, goldenrod is used to treat purulent wounds, furunculosis, and gum abscesses as washes and compresses. The aims of this research were to study the yield and chemical composition of essential oil (EO), the anti-inflammatory activity of S. canadensis dry extracts based on its decoction and tincture. In EO (2.8 mL/kg) of S. canadensis were identified and quantified 34 compounds. The principal compounds of the EO from flowering tops of S. canadensis were α-pinene (20.36%), β-copaene (16.16%), bornyl acetate (10.45%), D-limonene (8.21%), and β-elemene (6.80%). In the S. canadensis dry extracts were identified and quantified 20 phenolics (10 flavonoids, 8 hydroxycinnamic acids and 2 phenolic acids) and 14 amino acids, 7 of which are essential. The dominant hydroxycinnamic acids were neochlorogenic and chlorogenic acids, and 4,5-dicaffeoylquinic, 3,5-dicafeylquinic and 3,4-dicafeylquinic acids. The main flavonoids were rutin and isoquercitrin. The main amino acids (more than 1 mg/g) were proline, histidine, serine, alanine, aspartic acid, lysine and glutamic acid. The extracts of S. canadensis were characterized as practically non-toxic substances (toxicity class V). The extracts act on the exudative phase of inflammation. The antiexudative effect of the dry aqueous-alcohol S. canadensis extract was 23.59%, and for the aqueous one –19.26%. The dry aqueous-alcohol S. canadensis extract showed promising anti-inflammatory activity.

Graphical Abstract

Phytochemical and Pharmacological Research in Galenic Remedies of <i>Solidago canadensis</i> L. Herb

Keywords

Solidago canadensis; extract; essential oil; terpenoids; phenolics; amino acid; anti-inflammatory activity

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