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LUIS MANUEL GONZáLEZ-RODRíGUEZ¹, LUIS MIGUEL JUáREZ-SALCEDO^1,*, JAVIER LOSCERTALES¹, EVA ARRANZ¹, JIMENA CANNATA-ORTIZ¹, JAVIER ORTIZ¹, MARIA JOSé LóPEZ DE LA OSA¹, ADRIáN ALEGRE¹, SAMIR DALIA^2,*
Oncology Research, Vol.33, No.3, pp. 505-517, 2025, DOI:10.32604/or.2025.058175 - 28 February 2025
Abstract T-prolymphocytic leukemia is a rare and aggressive hematological malignancy characterized by the clonal proliferation of mature lymphoid T-cells. The pathogenesis of T-PLL is closely linked to specific chromosomal abnormalities, primarily involving the proto-oncogene T-cell leukemia/lymphoma 1 gene family. Recent advancements in molecular profiling have identified additional genomic aberrations, including those affecting the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway. This case report presents a patient with T-prolymphocytic leukemia whose cytogenetic and molecular analysis revealed a t(X;14)(q28;q11.2) translocation and a STAT5B mutation. Here, we aim to review the genetic and molecular underpinnings of T-prolymphocytic More >

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REVIEW

HYE IN KA^#, SE HWAN MUN^#, SORA HAN^#, YOUNG YANG^*
Oncology Research, Vol.33, No.3, pp. 519-531, 2025, DOI:10.32604/or.2024.056860 - 28 February 2025
Abstract Osteosarcoma is a bone malignancy characterized by strong invasiveness and rapid disease progression. The tumor microenvironment of osteosarcoma contains various types of immune cells, including myeloid-derived suppressor cells, macrophages, T cells, and B cells. Imbalances of these immune cells can promote the proliferation and metastasis of osteosarcoma. Recent studies have indicated a substantial increase in the levels of myeloid-derived suppressor cells, an immune cell associated with immunosuppressive and pro-cancer effects, in the peripheral blood of patients with osteosarcoma. Moreover, the levels of the pro-inflammatory cytokine interleukin 18 are positively correlated with those of myeloid-derived suppressor More >

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601

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REVIEW

IOANA MARIA MIHAI¹, GANG WANG^1,2,*
Oncology Research, Vol.33, No.3, pp. 533-547, 2025, DOI:10.32604/or.2024.055155 - 28 February 2025
（This article belongs to the Special Issue: Novel Targets and Biomarkers in Solid Tumors)
Abstract The advent of precision medicine has underscored the importance of biomarkers in predicting therapy response for bladder cancer, a malignancy marked by considerable heterogeneity. This review critically examines the current landscape of biomarkers to forecast treatment outcomes in bladder cancer patients. We explore a range of biomarkers, including genetic, epigenetic, proteomic, and transcriptomic indicators, from multiple sample sources, including urine, tumor tissue and blood, assessing their efficacy in predicting responses to chemotherapy, immunotherapy, and targeted therapies. Despite promising developments, the translation of these biomarkers into clinical practice faces significant challenges, such as variability in biomarker More >

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910

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483

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REVIEW

ZIYI FANG^1,2, YONGFU SHAO^1,2,*, MENG HU¹, JIANING YAN², GUOLIANG YE^2,*
Oncology Research, Vol.33, No.3, pp. 549-566, 2025, DOI:10.32604/or.2024.051589 - 28 February 2025
（This article belongs to the Special Issue: Novel Biomarkers and Treatment Strategies in Solid Tumor Diagnosis, Progression, and Prognosis)
Abstract Circular RNAs (circRNAs) are formed by splicing of precursor RNAs and covalently linked at the 5′ and 3′ ends. Dysregulated circRNAs are closely related to the epithelial-mesenchymal transition (EMT) of gastrointestinal malignancies. CircRNAs, including circRNA_0008717, circGOT1, circ-DOCK5, circVPS33B, circPVT1, circMET, circ-OXCT1, circ_67835, circRTN4, circ_0087502, circFNDC38, circ_PTEN1, circPGPEP1, and circ-E-Cad are involved in the EMT process of gastrointestinal malignancies through a variety of mechanisms, such as regulating EMT-inducing transcription factors, signaling pathways, and tumor microenvironments. Gastrointestinal (GI) malignancies are common malignant tumors worldwide, and the heterogeneity and easy metastasis of gastrointestinal malignancies limit the effectiveness of More >

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REVIEW

BAOXING HUANG^1,#, ZICHANG JIA^1,#, CHENCHEN FU², MOXIAN CHEN², ZEZHUO SU^3,*, YUNSHENG CHEN^1,*
Oncology Research, Vol.33, No.3, pp. 567-575, 2025, DOI:10.32604/or.2024.051672 - 28 February 2025
（This article belongs to the Special Issue: New Insights in Drug Resistance of Cancer Therapy: A New Wine in an Old Bottle)
Abstract Lipocalin-2 (LCN2) is a member of the lipocalin superfamily with multiple functions and can participate in the transport of a variety of small lipophilic ligands in vivo. LCN2 is significantly expressed in various tumors and plays an important role in regulating tumor cell proliferation, invasion, and metastasis. The specific actions of LCN2 in tumors may vary depending on the particular type of cancer involved. In this review, we provide an extensive overview of the transcriptional and post-transcriptional regulation of LCN2 in health and disease. Furthermore, we summarize the impact of LCN2 dysregulation in a broad range More >

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359

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REVIEW

YONG RAO^1,3,4, XIAO CHEN^5,6, KAIYU LI^1,3,4, MINHAI NIE^1,3,4, XUQIAN LIU^2,3,4,*
Oncology Research, Vol.33, No.3, pp. 577-590, 2025, DOI:10.32604/or.2024.053119 - 28 February 2025
Abstract Decorin (DCN) is primarily found in the connective tissues of various parts of the body, including the lungs, kidneys, bone tissue, aorta, and tendons. It is an important component of the extracellular matrix (ECM) and belongs to the class I small leucine-rich proteoglycans family. DCN is increasingly attracting attention due to its significant role in tumors, fibrotic diseases, and the regulation of vascular formation. Moreover, its anti-tumor properties have positioned it as a promising biomarker in the fight against cancer. Numerous studies have confirmed that DCN can exert inhibitory effects in various solid tumors, particularly… More >

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697

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REVIEW

RAHUL KUMAR SINGH^1,#, SUROJIT MANDAL^1,#, ADRIJA MOHANTA¹, RITU YADAV¹, RAJIV RANJAN KUMAR¹, RINKU KHATKAR¹, VIVEK UTTAM¹, UTTAM SHARMA¹, MANJIT KAUR RANA², MANJU JAIN³, HARDEEP SINGH TULI⁴, AKLANK JAIN^1,*
Oncology Research, Vol.33, No.3, pp. 591-604, 2025, DOI:10.32604/or.2024.050548 - 28 February 2025
Abstract Objectives: Recently, we and others have demonstrated the involvement of Zinc Finger Antisense 1 (ZFAS1) in cancer development. However, the intricate interplay of ZFAS1 with miRNAs and mRNAs remains to be fully understood. Materials and methods: We followed PRISMA guidelines to retrieve and assess the available literature on the topic “ZFAS1/miRNA/mRNA axis” and “Cancer” from databases such as PubMed, Google Scholar, and ScienceDirect. We also used bioinformatic webtools for analyzing the potential miRNA targets of ZFAS1 and its role in survival of cancer patients along with their role in various biological functions and pathways. Results: Our literature search… More >

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1258

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698

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ARTICLE

DONGYUN RONG^1,2,#, YUSHEN SU^1,#, ZHIRUI ZENG³, YAN YANG⁴, HONGUAN LU^1,*, YU CAO^1,*
Oncology Research, Vol.33, No.3, pp. 605-616, 2025, DOI:10.32604/or.2024.050661 - 28 February 2025
Abstract Background: Terpinen-4-ol (T4O), a key constituent of tea tree essential oil and various aromatic plants, has shown promising antiproliferative and pro-apoptotic effects in melanoma and other cancer types. However, its efficacy against cutaneous squamous cell carcinoma (cSCC) remains unclear. Thus, in this study, we investigated the in vivo and in vitro effects of T4O on cSCC cell lines and preliminarily explored its impacting pathways. Methods: Using CCK8 and assay colony formation, we assessed the viability of cSCC A431, SCL-1, and COLO-16 cells treated with T40 at varying concentrations (0, 1, 2, and 4 μM). Flow cytometry was… More >

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440

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KE TIAN¹, ZHIPENG LI², XIANGYU ZHAI^2,3, HUAXIN ZHOU², HUI YAO^1,*
Oncology Research, Vol.33, No.3, pp. 617-630, 2025, DOI:10.32604/or.2024.049772 - 28 February 2025
（This article belongs to the Special Issue: Novel Biomarkers and Treatment Strategies in Solid Tumor Diagnosis, Progression, and Prognosis)
Abstract Background: Primary liver cancer poses a significant global health burden, with projections indicating a surpassing of one million cases by 2025. Cuproptosis, a copper-dependent mechanism of cell death, plays a crucial role in the pathogenesis, progression, and prognosis of various cancers, including hepatocellular carcinoma (HCC). Purpose: This study aimed to develop a prognostic model for HCC based on cuproptosis-related genes, utilizing clinical data and gene expression profiles from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Materials and Methods: Clinical features and gene expression data of HCC patients were collected from publicly available More >

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716

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ARTICLE

HUAFANG HUANG^1,2,#, GUILIN WANG^3,#, DONGYUN ZENG^4,5, LUZ ANGELA TORRES-DE LA ROCHE², RUI ZHUO^1,2, RUDY LEON DE WILDE², WANWAN WANG⁶, ULF D. KAHLERT^7,*, WENJIE SHI^7,*
Oncology Research, Vol.33, No.3, pp. 631-640, 2025, DOI:10.32604/or.2024.054642 - 28 February 2025
（This article belongs to the Special Issue: New Insights in Drug Resistance of Cancer Therapy: A New Wine in an Old Bottle)
Abstract Background: Neoadjuvant chemotherapy (NAC) significantly enhances clinical outcomes in patients with triple-negative breast cancer (TNBC); however, chemoresistance frequently results in treatment failure. Consequently, understanding the mechanisms underlying resistance and accurately predicting this phenomenon are crucial for improving treatment efficacy. Methods: Ultrasound images from 62 patients, taken before and after neoadjuvant therapy, were collected. Mitochondrial-related genes were extracted from a public database. Ultrasound features associated with NAC resistance were identified and correlated with significant mitochondrial-related genes. Subsequently, a prognostic model was developed and evaluated using the GSE58812 dataset. We also assessed this model alongside clinical factors… More >

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553

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ARTICLE

LI SUN^1,#, SHICHAO ZHUO^2,#, XIAOXIN LI², HUSHENG KONG³, WEIWEI DU³, CHONG ZHOU⁴, JUNXING HUANG^1,*
Oncology Research, Vol.33, No.3, pp. 641-651, 2025, DOI:10.32604/or.2024.050057 - 28 February 2025
（This article belongs to the Special Issue: New Insights in Drug Resistance of Cancer Therapy: A New Wine in an Old Bottle)
Abstract Background: Cisplatin (DDP) has been used in the treatment of various human cancers. However, DDP alone lacks efficacy in treating triple-negative breast cancer (TNBC), and its clinical application is often hampered by side effects. Astragalus polysaccharide (APS) is one of the active components extracted from Astragalus membranaceus and has gained attention for its various biological properties. This research is aimed to evaluate the effectiveness of a combination of APS and DDP on TNBC and explore the potential mechanisms. Methods: The efficacy and mechanisms of single or combined treatment were evaluated using Cell Counting Kit-8 (CCK8) assay, Annexin… More >

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DAIEN ZHOU^1,#, HAOYANG YUAN^2,#, YIWEI HU³, CHUXU WANG¹, SA GE¹, KOUFENG SHAO⁴, HONGYING WANG¹, XIAOFENG TIAN^1,*, HAIBO HU^1,*
Oncology Research, Vol.33, No.3, pp. 653-663, 2025, DOI:10.32604/or.2024.050182 - 28 February 2025
（This article belongs to the Special Issue: New Insights in Drug Resistance of Cancer Therapy: A New Wine in an Old Bottle)
Abstract Background: Despite the identification of numerous therapeutic targets in lung cancer, achieving significant efficacy has been challenging. TNFRSF21 plays an important role in various cancers. We investigated the function of TNFRSF21 in lung adenocarcinoma (LUAD). Methods: The prognostic value of TNFRSF21 expression in lung cancer was evaluated by the GEPIA and Kaplan-Meier Plotter databases. Lung cancer cell viability was assessed by the CCK8 assay. TNFRSF21 expression patterns in lung cancer tissues and cells were examined using RT-PCR assay. Tumor sphere growth was evaluated through tumor sphere formation assays. MtROS contents in lung cancer cells were… More >

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1104

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441

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RAZIEH MOMEN-MESGIN¹, JAFAR REZAIE^2,*, VAHID NEJATI¹, PEYMAN NAJAFI MOGHADAM³
Oncology Research, Vol.33, No.3, pp. 665-674, 2025, DOI:10.32604/or.2024.054487 - 28 February 2025
Abstract Objectives: Due to systematic side effects, there is a growing interest in nanoparticle formulation of anticancer drugs. Here, we aimed to synthesize poly (styrene-alt-maleic anhydride) cross-linked by melamine (PSMA/Me) and coated with magnetite nanoparticles (MNPs) PSMA/Me/Fe₃O₄. In addition, we aimed to load paclitaxel (PTX) into PSMA/Me/Fe₃O₄ for drug delivery and anticancer investigations. Methods: Novel PSMA/Me was synthesized via free radical copolymerization, coated with Fe₃O₄, and then used as a transporter for PTX delivery. Fabricated copolymer was characterized using SEM, TGA, and XRD techniques. Drug release rate and loading efficiency were investigated. Human ovarian cancer cells (Skov-3) and… More >

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852

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377

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MOHAMMAD ABOHASSAN, MESFER MOHAMMAD AL SHAHRANI, SARAH KHALED ALOUDA, PRASANNA RAJAGOPALAN^*
Oncology Research, Vol.33, No.3, pp. 675-685, 2025, DOI:10.32604/or.2024.056256 - 28 February 2025
Abstract Background: The JAK2^V617F mutation plays a crucial part in the pathogenesis of myeloproliferative neoplasms (MPN), which includes polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) leading to aberrant proliferation and survival of hematopoietic cells. Alongside the challenges of drug resistance and side effects, identifying novel compounds that selectively target JAK2^V617F could provide more effective and safer therapeutic options for patients with MPNs. Materials and Methods: We employed computational approaches like high-throughput virtual screening, molecular dynamics simulations (MDS), and binding free energy calculations to identify inhibitors targeting wild and mutant JAK2 kinases. JAK2^V617F positive HEL, wild… More >

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SHUANG CHEN^1,2,#, XUEMEI DENG^2,#, XINGTING HE², KEWEI XIANG², GUIHONG CHEN², HONGRU YANG^2,*
Oncology Research, Vol.33, No.3, pp. 687-694, 2025, DOI:10.32604/or.2024.052133 - 28 February 2025
Abstract Background: Previous experiments have demonstrated that hypofractionated radiation therapy (HFRT), low-dose radiation therapy (LDRT), and combined anti-programmed cell death protein 1 (αPD-1) can enhance the abscopal effect. Combined with the phenomenon of low prognosis in patients with breast cancer lung metastasis, our study establishes a mouse model and changes the irradiation regimen of LDRT to explore its preventive effect on breast cancer lung metastasis. Methods: The breast cancer subcutaneous graft tumor model was developed. Two-lung prophylactic LDRT was performed prior to the onset of lung metastases, in combination with HFRT (8 Gy, 3f), and αPD-1… More >

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YULIAN WANG¹, LIANLI ZHU¹, RONGHAO ZENG², YUNPING PU³, BAIJIAN CHEN³, YUWEI TAN³, MING HONG^2,*, WEIJIA WANG^1,2,*
Oncology Research, Vol.33, No.3, pp. 695-708, 2025, DOI:10.32604/or.2024.051746 - 28 February 2025
Abstract Background: The role of 1,25-dihydroxyvitamin D3 (1,25-(OH)₂D₃) in cancer prevention and treatment is an emerging topic of interest. However, its effects on the stemness of acute myeloid leukemia (AML) cells are poorly understood. Methods: The proliferation and differentiation of AML cells (HL60 and NB4) were investigated by the CCK-8 assay, immunocytochemical staining, and flow cytometry. The abilities of HL60 and NB4 cells to form spheres were examined by the cell sphere formation assay. In addition, the levels of stemness-associated markers (SOX2, Nanog, OCT4, and c-Myc) in HL60 and NB4 cells were measured by western blotting and… More >

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1276

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538

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DONG JIANG¹, ZHI QI³, ZHIYING XU^2,*, YIRAN LI^1,*
Oncology Research, Vol.33, No.3, pp. 709-722, 2025, DOI:10.32604/or.2024.050125 - 28 February 2025
Abstract Background: Hepatocellular carcinoma (HCC) is a prevalent liver malignancy. This study examined the roles of transforming growth factor beta (TGF-β) and cytochrome b5 domain containing 2 (CYB5D2) in HCC etiology and their prognostic biomarker potential. Methods: Key modules and prognostic genes were identified by analyzing the GSE101685 dataset by weighted gene co-expression network analysis (WGCNA) and Least absolute shrinkage and selection operator (LASSO) Cox regression. The expression levels of CYB5D2 and TGF-β in HCC cell lines were quantified using Quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Western blotting (WB) assays. Effects of CYB5D2 overexpression on cell proliferation,… More >

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BELARDINILLI FRANCESCA^1,#, MICHELA DE MEO^1,#, FRANCESCO DEL GIUDICE², CARLO MARIA SCORNAJENGHI², PAOLA GAZZANIGA¹, ETTORE DE BERARDINIS², LUCA MARINO³, FABIO MASSIMO MAGLIOCCA⁴, BENJAMIN INBEH CHUNG⁵, JAN ŁASZKIEWICZ⁶, VALENTINA MAGRI⁴, GIUSEPPE GIANNINI^1,7, CHIARA NICOLAZZO^1,*
Oncology Research, Vol.33, No.3, pp. 723-731, 2025, DOI:10.32604/or.2024.056282 - 28 February 2025
Abstract Objectives: Intravesical Bacillus Calmette-Guérin (BCG) therapy is a gold standard for patients with high-risk non-muscle invasive bladder cancer (NMIBC). Although a long-lasting therapeutic response is observed in most patients, BCG failure occurs in 30%–50% of patients and a progression to muscle-invasive disease is found in 10%–15%. Therefore, predicting high-risk patients who might not benefit from BCG treatment is critical. The purpose of this study was to identify, whether the presence of specific oncogenic mutations might be indicative of BCG treatment response. Methods: Nineteen high-grade NMIBC patients who received intravesical BCG were retrospectively enrolled and divided… More >

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Oncology Research Editorial Office
Oncology Research, Vol.33, No.3, pp. 733-733, 2025, DOI:10.32604/or.2024.056906 - 28 February 2025
Abstract This article has no abstract. More >

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474

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194

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Oncology Research Editorial Office
Oncology Research, Vol.33, No.3, pp. 735-735, 2025, DOI:10.32604/or.2024.056907 - 28 February 2025
Abstract This article has no abstract. More >

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430

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200

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Oncology Research Editorial Office
Oncology Research, Vol.33, No.3, pp. 737-737, 2025, DOI:10.32604/or.2024.056910 - 28 February 2025
Abstract This article has no abstract. More >

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392

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155

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RETRACTION

Oncology Research Editorial Office
Oncology Research, Vol.33, No.3, pp. 739-739, 2025, DOI:10.32604/or.2024.056911 - 28 February 2025
Abstract This article has no abstract. More >

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442

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178