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Non-canonical BRAF variants and rearrangements in hairy cell leukemia

STEPHEN E. LANGABEER*

Cancer Molecular Diagnostics, St. James’s Hospital, Dublin, D08 W9RT, Ireland

* Corresponding Author: STEPHEN E. LANGABEER. Email: email

Oncology Research 2024, 32(9), 1423-1427. https://doi.org/10.32604/or.2024.051218

Abstract

Hairy cell leukemia (HCL) is an uncommon mature B-cell malignancy characterized by a typical morphology, immunophenotype, and clinical profile. The vast majority of HCL patients harbor the canonical BRAF V600E mutation which has become a rationalized target of the subsequently deregulated RAS-RAF-MEK-MAPK signaling pathway in HCL patients who have relapsed or who are refractory to front-line therapy. However, several HCL patients with a classical phenotype display non-canonical BRAF mutations or rearrangements. These include sequence variants within alternative exons and an oncogenic fusion with the IGH gene. Care must be taken in the molecular diagnostic work-up of patients with typical HCL but without the BRAF V600E to include investigation of these uncommon mechanisms. Identification, functional characterization, and reporting of further such patients is likely to provide insights into the pathogenesis of HCL and enable rational selection of targeted inhibitors in such patients if required.

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Cite This Article

APA Style
LANGABEER, S.E. (2024). Non-canonical braf variants and rearrangements in hairy cell leukemia. Oncology Research, 32(9), 1423-1427. https://doi.org/10.32604/or.2024.051218
Vancouver Style
LANGABEER SE. Non-canonical braf variants and rearrangements in hairy cell leukemia. Oncol Res. 2024;32(9):1423-1427 https://doi.org/10.32604/or.2024.051218
IEEE Style
S.E. LANGABEER, “Non-canonical BRAF variants and rearrangements in hairy cell leukemia,” Oncol. Res., vol. 32, no. 9, pp. 1423-1427, 2024. https://doi.org/10.32604/or.2024.051218



cc Copyright © 2024 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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