Open Access

ARTICLE

IL13RA2 promotes progression of infantile haemangioma by activating glycolysis and the Wnt/β-catenin signaling pathway

by ZIYONG LIU^1,#, TAO MA^1,#, JINFANG LI², WEI REN^1,*, ZHIXIN ZHANG^1,*

1 Department of Cardiothoracic Surgery, 970th Hospital of the People’s Liberation Army, Weihai, 264209, China
2 Department of Cardiac Ultrasound, Weihai Municipal Hospital, Weihai, 264200, China

* Corresponding Authors: WEI REN. Email: ; ZHIXIN ZHANG. Email:

Oncology Research 2024, 32(9), 1453-1465. https://doi.org/10.32604/or.2024.048315

Received 04 December 2023; Accepted 01 February 2024; Issue published 23 August 2024

Abstract

Background: Interleukin 13 receptor subunit alpha 2 (IL13RA2) plays an essential role in the progression of many cancers. However, the role of IL13RA2 in infantile haemangioma (IH) is still unknown. Materials and Methods: IL13RA2 expression in IH tissues was analyzed using western blot, qRT-PCR, and immunofluorescence. The role of IL13RA2 in haemangioma-derived endothelial cells (HemECs) was determined following knockdown or overexpression of IL13RA2 using CCK-8, colony formation, apoptosis, wound healing, tubule formation, Transwell, and western blot. Results: IL13RA2 expression was upregulated in IH tissues. IL13RA2 overexpression promoted proliferation, migration, and invasion of HemECs and induced glycolysis, which was confirmed with a glycolysis inhibitor. Specifically, IL13RA2 interacted with β-catenin and activated the Wnt/β-catenin pathway in HemECs, which were involved in the above-mentioned effects of IL13RA2. Conclusions: These findings revealed that targeting IL13RA2 is a potential therapeutic approach for IH.

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Keywords

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