Open Access

ARTICLE

Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling

MAKOTO KAWATANI^1,2,*, HARUMI AONO², SAYOKO HIRANUMA³, TAKESHI SHIMIZU³, MAKOTO MUROI^1,2, TOSHIHIKO NOGAWA⁴, TOMOKAZU OHISHI⁵, SHUN-ICHI OHBA⁵, MANABU KAWADA⁵, KANAMI YAMAZAKI⁶, SHINGO DAN⁶, NAOSHI DOHMAE¹, HIROYUKI OSADA^2,7,*

1 Biomolecular Characterization Unit, Technology Platform Division, RIKEN Center for Sustainable Resource Science (CSRS), Saitama, 351-0198, Japan
2 Chemical Resource Development Unit, Technology Platform Division, RIKEN Center for Sustainable Resource Science (CSRS), Saitama, 351-0198, Japan
3 Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science (CSRS), Saitama, 351-0198, Japan
4 Molecular Structure Characterization Unit, Technology Platform Division, RIKEN Center for Sustainable Resource Science (CSRS), Saitama, 351-0198, Japan
5 Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Shizuoka, 410-0301, Japan
6 Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japan Foundation for Cancer Research, Tokyo, 135-8550, Japan
7 Department of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, 422-8526, Japan

* Corresponding Authors: MAKOTO KAWATANI. Email: ; HIROYUKI OSADA. Email: