Open Access

ARTICLE

The DMRTA1-SOX2 positive feedback loop promotes progression and chemotherapy resistance of esophageal squamous cell carcinoma

RUI ZHANG^1,2,#, PENG ZHOU^1,3,#, XIA OU⁴, PEIZHU ZHAO², XIJING GUO², MIAN XI^5,*, CHEN QING^1,*

1 School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, China
2 Department of Radiotherapy, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China
3 Department of Pharmacy, The Second Affiliated Hospital of Kunming Medical University, Kunming, 650101, China
4 Medical School, Kunming University of Science and Technology, Kunming, 650504, China
5 Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China

* Corresponding Authors: MIAN XI. Email: ; CHEN QING. Email:
# Rui Zhang and Peng Zhou have contributed equally to this work