Open Access

REVIEW

Progress in research on tumor microenvironment-based spatial omics technologies

by FANGMEI XIE^1,#, NAITE XI^1,#, ZEPING HAN^1,#, WENFENG LUO¹, JIAN SHEN¹, JINGGENG LUO², XINGKUI TANG², TING PANG¹, YUBING LV¹, JIABING LIANG¹, LIYIN LIAO¹, HAOYU ZHANG¹, YONG JIANG¹, YUGUANG LI^3,*, JINHUA HE^1,*

1 Central Laboratory, Panyu Central Hospital of Guangzhou, Guangzhou, China
2 Department of General Surgery, Panyu Central Hospital of Guangzhou, Guangzhou, China
3 Administrating Office, He Xian Memorial Hospital, Southern Medical University, Guangzhou, China

* Corresponding Authors: YUGUANG LI. Email: ; JINHUA HE. Email:
# These authors contributed equally to this work

Oncology Research 2023, 31(6), 877-885. https://doi.org/10.32604/or.2023.029494

Received 22 February 2023; Accepted 21 June 2023; Issue published 15 September 2023

Abstract

Spatial omics technology integrates the concept of space into omics research and retains the spatial information of tissues or organs while obtaining molecular information. It is characterized by the ability to visualize changes in molecular information and yields intuitive and vivid visual results. Spatial omics technologies include spatial transcriptomics, spatial proteomics, spatial metabolomics, and other technologies, the most widely used of which are spatial transcriptomics and spatial proteomics. The tumor microenvironment refers to the surrounding microenvironment in which tumor cells exist, including the surrounding blood vessels, immune cells, fibroblasts, bone marrow-derived inflammatory cells, various signaling molecules, and extracellular matrix. A key issue in modern tumor biology is the application of spatial omics to the study of the tumor microenvironment, which can reveal problems that conventional research techniques cannot, potentially leading to the development of novel therapeutic agents for cancer. This paper summarizes the progress of research on spatial transcriptomics and spatial proteomics technologies for characterizing the tumor immune microenvironment.

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