Open Access

ARTICLE

Identification of microbial metabolites that accelerate the ubiquitin-dependent degradation of c-Myc

ZIYU LIU^1,2, AKIKO OKANO^3,4, EMIKO SANADA^1,3,4, YUSHI FUTAMURA^3,4, TOSHIHIKO NOGAWA^3,5, KOSUKE ISHIKAWA⁶, KENTARO SEMBA^7,8, JIANG LI⁹, XIAOMENG LI¹⁰, HIROYUKI OSADA^3,4,11,*, NOBUMOTO WATANABE^1,2,4,*

1 Bioprobe Application Research Unit, RIKEN CSRS, Saitama, 351-0198, Japan
2 Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, 113-8510, Japan
3 Chemical Biology Research Group, RIKEN CSRS, Saitama, 351-0198, Japan
4 Chemical Resource Development Research Unit, RIKEN CSRS, Saitama, 351-0198, Japan
5 Molecular Structure Characterization Unit, RIKEN CSRS, Saitama, 351-0198, Japan
6 Japan Biological Informatics Consortium (JBIC), Tokyo, 135-8073, Japan
7 Department of Life Science and Medical Bioscience, School of Advanced Science and Engineering, Waseda University, Tokyo, 162-8480, Japan
8 Medical-Industrial Translational Research Center, Fukushima Medical University, Fukushima, 960-1295, Japan
9 Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou, China
10 KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, China
11 Department of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, 422-8526, Japan

* Corresponding Authors: HIROYUKI OSADA. Email: ; NOBUMOTO WATANABE. Email: