Open Access
ARTICLE
Apolipoprotein C1 promotes tumor progression in gastric cancer
QIOU GU, TIAN ZHAN, XIAO GUAN, CHUILIN LAI, NA LU, GUOGUANG WANG, LEI XU, XIANG GAO, JIANPING ZHANG*
Department of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210009, China
* Corresponding Author: Jianping Zhang,
(This article belongs to this Special Issue: Transcriptome Analysis in Tumor Microenvironment and Tumor Heterogeneity)
Oncology Research 2023, 31(3), 287-297. https://doi.org/10.32604/or.2023.028124
Received 30 November 2022; Accepted 15 February 2023; Issue published 22 May 2023
Abstract
Background: Gastric cancer (GC) is a malignancy with the worst prognosis that seriously threatens human
health, especially in East Asia. Apolipoprotein C1 (
apoc1) belongs to the apolipoprotein family. In addition,
apoc1 has
been associated with various tumors. However, its role in GC remains unclear.
Methods: Firstly, we quantified its
expression in GC and adjacent tumor tissues, using The Cancer Genome Atlas (TCGA). Next, we assessed cell
invasion and migration abilities. Finally, we revealed the role of
apoc1 in the tumor microenvironment (TME),
immune cell infiltration and drug sensitivity.
Results: Firstly, in TCGA database, it has been shown that elevated
expression of
apoc1 was identified in various cancers, including GC, then we found that high expression of
apoc1 was
significantly correlated with poor prognosis in GC. Histologically,
apoc1 expression is proportional to grade, cancer
stage, and T stage. The experimental results showed that
apoc1 promoted cell invasion and migration. Then GO,
KEGG, and GSEA pathway analyses indicated that
apoc1 may be involved in the WNT pathway and immune
regulation. Furthermore, we found out the tumor-infiltrating immune cells related to
apoc1 in the tumor
microenvironment (TME) using TIMER. Finally, we investigated the correlation between
apoc1 expression and drug
sensitivity, PD-1 and CTLA-4 therapy.
Conclusions: These results suggest that
apoc1 participates in the evolution of
GC, and may represent a potential target for detection and immunotherapy in GC.
Keywords
Cite This Article
GU, Q., ZHAN, T., GUAN, X., LAI, C., LU, N. et al. (2023). Apolipoprotein C1 promotes tumor progression in gastric cancer.
Oncology Research, 31(3), 287–297.