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Progress on diagnostic and prognostic markers of pancreatic cancer

HONG YANG1,2, WAN LI1,2, LIWEN REN1,2, YIHUI YANG1,2, YIZHI ZHANG1,2, BINBIN GE1,2, SHA LI1,2, XIANGJIN ZHENG1,2, JINYI LIU1,2, SEN ZHANG1,2, GUANHUA DU1,2, BO TANG3, HONGQUAN WANG3, JINHUA WANG1,2,*

1 The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing, 100050, China
2 Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China
3 Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China

* Corresponding Author: JINHUA WANG. Email: email

Oncology Research 2023, 31(2), 83-99. https://doi.org/10.32604/or.2023.028905

Abstract

Pancreatic cancer is a malignant disease characterized by low survival and high recurrence rate, whose patients are mostly at the stage of locally advanced or metastatic disease when first diagnosed. Early diagnosis is particularly important because prognostic/predictive markers help guide optimal individualized treatment regimens. So far, CA19-9 is the only biomarker for pancreatic cancer approved by the FDA, but its effectiveness is limited by low sensitivity and specificity. With recent advances in genomics, proteomics, metabolomics, and other analytical and sequencing technologies, the rapid acquisition and screening of biomarkers is now possible. Liquid biopsy also occupies a significant place due to its unique advantages. In this review, we systematically describe and evaluate the available biomarkers that have the greatest potential as vital tools in diagnosing and treating pancreatic cancer.

Graphic Abstract

Progress on diagnostic and prognostic markers of pancreatic cancer

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Cite This Article

APA Style
YANG, H., LI, W., REN, L., YANG, Y., ZHANG, Y. et al. (2023). Progress on diagnostic and prognostic markers of pancreatic cancer. Oncology Research, 31(2), 83-99. https://doi.org/10.32604/or.2023.028905
Vancouver Style
YANG H, LI W, REN L, YANG Y, ZHANG Y, GE B, et al. Progress on diagnostic and prognostic markers of pancreatic cancer. Oncol Res. 2023;31(2):83-99 https://doi.org/10.32604/or.2023.028905
IEEE Style
H. YANG et al., “Progress on diagnostic and prognostic markers of pancreatic cancer,” Oncol. Res., vol. 31, no. 2, pp. 83-99, 2023. https://doi.org/10.32604/or.2023.028905



cc Copyright © 2023 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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