Open Access

ARTICLE

Macrophage-derived SHP-2 inhibits the metastasis of colorectal cancer via Tie2-PI3K signals

XUELIANG WU^1,#, SHAOYU GUAN^2,#, YONGGANG LU³, JUN XUE⁴, XIANGYANG YU¹, QI ZHANG^5,*, XIMO WANG^1,5,*, TIAN LI⁶

1 Department of Gastrointestinal Surgery, Tianjin Medical University Nankai Hospital, Tianjin, 300100, China
2 93868 Troop of the Chinese People’s Liberation Army, Yinchuan, 750021, China
3 Clinical Laboratory, Hebei General Hospital, Shijiazhuang, 050051, China
4 Department of General Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, China
5 Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Institute of Integrative Medicine for Acute Abdominal Diseases, Integrated Chinese and Western Medicine Hospital, Tianjin University, Tianjin, 300100, China
6 School of Basic Medicine, Fourth Military Medical University, Xi’an, 710032, China

* Corresponding Authors: Ximo Wang, ; Qi Zhang,
# Equal contribution