TY - EJOU AU - ZHONG, JIATENG AU - GUO, JINGYU AU - ZHANG, XINYU AU - FENG, SHUANG AU - DI, WENYU AU - WANG, YANLING AU - ZHU, HUIFANG TI - The remodeling roles of lipid metabolism in colorectal cancer cells and immune microenvironment T2 - Oncology Research PY - 2022 VL - 30 IS - 5 SN - 1555-3906 AB - Lipid is a key component of plasma membrane, which plays an important role in the regulation of various cell biological behaviors, including cell proliferation, growth, differentiation and intracellular signal transduction. Studies have shown that abnormal lipid metabolism is involved in many malignant processes, including colorectal cancer (CRC). Lipid metabolism in CRC cells can be regulated not only by intracellular signals, but also by various components in the tumor microenvironment, including various cells, cytokines, DNA, RNA, and nutrients including lipids. In contrast, abnormal lipid metabolism provides energy and nutrition support for abnormal malignant growth and distal metastasis of CRC cells. In this review, we highlight the remodeling roles of lipid metabolism crosstalk between the CRC cells and the components of tumor microenvironment. KW - Lipid metabolism KW - Colorectal cancer KW - Tumor microenvironment (TME) DO - 10.32604/or.2022.027900