Open Access

REVIEW

The remodeling roles of lipid metabolism in colorectal cancer cells and immune microenvironment

by JIATENG ZHONG^1,2, JINGYU GUO¹, XINYU ZHANG¹, SHUANG FENG¹, WENYU DI², YANLING WANG^3,*, HUIFANG ZHU^1,*

1 Department of Pathology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, 453003, China
2 Department of Pathology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453100, China
3 Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China

* Corresponding Authors: Huifang Zhu, ; Yanling Wang,

Oncology Research 2022, 30(5), 231-242. https://doi.org/10.32604/or.2022.027900

Received 20 November 2022; Accepted 18 January 2023; Issue published 03 February 2023

Abstract

Lipid is a key component of plasma membrane, which plays an important role in the regulation of various cell biological behaviors, including cell proliferation, growth, differentiation and intracellular signal transduction. Studies have shown that abnormal lipid metabolism is involved in many malignant processes, including colorectal cancer (CRC). Lipid metabolism in CRC cells can be regulated not only by intracellular signals, but also by various components in the tumor microenvironment, including various cells, cytokines, DNA, RNA, and nutrients including lipids. In contrast, abnormal lipid metabolism provides energy and nutrition support for abnormal malignant growth and distal metastasis of CRC cells. In this review, we highlight the remodeling roles of lipid metabolism crosstalk between the CRC cells and the components of tumor microenvironment.

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Keywords

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