Open Access

ARTICLE

The synergistic effects of PRDX5 and Nrf2 on lung cancer progression and drug resistance under oxidative stress in the zebrafish models

SITONG QIAN^1,2,#, YING FANG^1,#, CHENGYUN YAO^1,#, YONGSHENG WANG^3,#, ZHI ZHANG¹, XIAOHUA WANG¹, JIN GAO¹, YONG FENG¹, LEI SUN¹, RUNYUE ZOU², GUOREN ZHOU^1,*, JINJUN YE^1,*, RUIXUE XIA^4,*, HONGPING XIA^5,6,*

1 Jiangsu Cancer Hospital, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Institute of Cancer Research, Nanjing, 210009, China
2 School of Life Sciences, Nanjing Normal University, Nanjing, 210046, China
3 Department of Respiratory Medicine, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, 210008, China
4 Medical College of Henan University & Henan University Huaihe Hospital, Kaifeng, 475000, China
5Zhongda Hospital, School of Medicine & Advanced Institute for Life and Health, Southeast University, Nanjing, 210009, China
6 Department of Pathology, Nanjing Drum Tower Hospital & Drum Tower Clinical College & School of Basic Medical Sciences & Key Laboratory of Antibody Technique of National Health Commission & Jiangsu Antibody Drug Engineering Research Center, Nanjing Medical University, Nanjing, 211166, China

* Corresponding Authors: GUOREN ZHOU. Email: ; JINJUN YE. Email: ; RUIXUE XIA. Email: ; HONGPING XIA. Email:
# These authors contributed equally to this work