Open Access
CASE REPORT
JOÃO OLIVEIRA PEREIRA1,2,*, JOÃO GAMA3, DIANA FERREIRA2,4, ARSÉNIO SANTOS2,4
Oncology Research, Vol.29, No.2, pp. 81-85, 2021, DOI:10.32604/or.2022.023450
Abstract Hypercalcaemia and leukocytosis are two paraneoplastic conditions associated with poor prognosis.
Adenosquamous carcinoma is a rare and aggressive histological subtype of lung cancer consisting of adenocarcinoma
and squamous cell components. We report the case of a 57-year-old male smoker who was admitted to the Emergency
Room with skull and neck tumefactions, confusion and deteriorated general condition. The complementary study in the
ER revealed severe hypercalcaemia (19.8 mg/dL), leukocytosis (18.7 × 109
/L) and extensive osteolytic lesions of the skull
on cranioencephalic computer tomography (CT). The patient was stabilized and admitted. Thoracoabdominopelvic CT
showed lung parenchyma consolidation with necrotic areas, supra… More >
Open Access
ARTICLE
BIN LIU1,2,#, HAIPENG LIU3,#, FEIFEI REN1,2, HANGFAN LIU1, IHTISHAM BUKHARI1, YUMING FU4, WANQING WU4, MINGHAI ZHAO5, SHAOGONG ZHU6, HUI MO1, FAZHAN LI1,2, MICHAEL B. ZHENG7, YOUCAI TANG1,2, PENGYUAN ZHENG1,2,*, YANG MI1,2,*
Oncology Research, Vol.29, No.2, pp. 87-103, 2021, DOI:10.32604/or.2022.03529
Abstract The activation of some oncogenes promote cancer cell proliferation and growth, facilitate cancer progression
and metastasis by induce DNA replication stress, even genome instability. Activation of the cyclic GMP-AMP synthase
(cGAS) mediates classical DNA sensing, is involved in genome instability, and is linked to various tumor development or
therapy. However, the function of cGAS in gastric cancer remains elusive. In this study, the TCGA database and
retrospective immunohistochemical analyses revealed substantially high cGAS expression in gastric cancer tissues and
cell lines. By employing cGAS high-expression gastric cancer cell lines, including AGS and MKN45, ectopic silencing
of cGAS caused a significant… More >
Open Access
ARTICLE
ZHEN JIA1,2,#, ZHENGTING QIAN1,2,#, YONG TANG2, XIANG LI2, YAN SHI2, HENG XIN1,2, YOUWU FAN1,2,*, HEMING WU2,*
Oncology Research, Vol.29, No.2, pp. 105-117, 2021, DOI:10.32604/or.2022.03536
Abstract Glioma is a general malignant tumor with a dismal prognosis. Long noncoding RNAs (lncRNAs) have been
implicated in the initiation and processes of tumors. An investigation of the GEPIA database revealed that long
noncoding RNA WEE2 antisense RNA 1 (WEE2-AS1) is upregulated in glioma tissues compared to normal brain
tissues, and validation with quantitative real-time polymerase chain reaction (qRT–PCR) revealed that WEE2-AS1
expression was consistent with the database prediction. Fluorescence in situ hybridization (FISH) assays revealed that
WEE2-AS1 was localized primarily in the cytoplasm. Clone formation experiment and EDU assay were used to detect
cell proliferation ability, and Transwell assay… More >
Open Access
ARTICLE
JIALIN WU1,2,#, ZEHONG CHEN3, WENWEI LIU1,#, YONGXIN ZHANG1, WEI FENG1, YUJIE YUAN1, JINNING YE1, LIANG WANG1, SHIRONG CAI1, YULONG HE1, SUIJING WU4,*, WU SONG1,*
Oncology Research, Vol.29, No.2, pp. 119-128, 2021, DOI:10.32604/or.2022.03178
Abstract Objective: MicroRNA-188-5p (miR-188) enhances oncologic progression in various human malignancies. This
study aimed to explore its role in colorectal cancer (CRC). Materials and Methods: Human CRC tissues paired with
normal tissues, and several CRC cell lines were utilized. Real-time quantitative PCR was applied to measure the
expression of miR-188. Overexpression and knockdown were used to access the function of miR-188 and to
investigate whether FOXL1/Wnt signaling mediates such function. The proliferation, migration and invasion of cancer
cells were evaluated by CCK8, wound-healing and transwell assays, respectively. Whether FOXL1 acted as a direct
target of miR-188 was verified by dual-luciferase reporter… More >
Open Access
ARTICLE
YANG ZHANG, LIXIA MA, TINGTING ZHANG, PEIDONG LI, JIABIN XU, ZHUO WANG*
Oncology Research, Vol.29, No.2, pp. 129-139, 2021, DOI:10.32604/or.2022.03563
Abstract In this study, we mainly focus on probing expression profile and detailed functions of long non-coding RNA
TFAP2A antisense RNA 1 (TFAP2A-AS1) in non-small cell lung cancer (NSCLC). Moreover, the mechanisms played by
TFAP2A-AS1 were unraveled comprehensively. Herein, a notable overexpressed TFAP2A-AS1 in NSCLC was observed
by TCGA and our own cohort. An increased TFAP2A-AS1 level displayed a negative correlation with the overall survival
of patients with NSCLC. Loss-of-function approaches illustrated that the absence of TFAP2A-AS1 weakened NSCLC cell
proliferation, colony formation, migration and invasion in vitro. Also, interference of TFAP2A-AS1 caused in vivo tumor
growth suppression. Mechanistically, TFAP2A-AS1 could… More >
Open Access
ARTICLE
NIMA HEMMAT1, MOHAMMAD AMIN DOUSTVANDI1, ZAHRA ASADZADEH1, AHAD MOKHTARZADEH1, BEHZAD BARADARAN1,4,*, HOSSEIN BANNAZADEH BAGHI1,2,3,*
Oncology Research, Vol.29, No.2, pp. 141-148, 2021, DOI:10.32604/or.2022.023346
Abstract Cervical cancer is a growing global disease in developing countries. Persistent infection with human
papillomaviruses (HPV) is an essential causative agent in this type of cancer. Several studies demonstrate HPV E5
oncoprotein can impress the normal life cycle of HPV-infected cells by targeting some pivotal cellular signaling
pathways, such as the epidermal growth factor receptor (EGFR) signaling pathway. In this study, we used E5-siRNA
to knockdown that essential oncogene and considered the effect of E5 silencing on proliferation, apoptosis, cell cycle,
apoptosis-related gene expression, and the initiator of the EGFR signaling pathway in cervical cancer cells. The results
demonstrate that… More >
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