Open Access
ERRATUM
Kallistatin Suppresses Cell Proliferation and Invasion and Promotes Apoptosis in Cervical Cancer Through Blocking NF-κB Signaling
Tao Wang, Fan Shi, JiQuan Wang, Zi Liu, Jin Su
Department of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, P.R. China
Oncology Research 2020, 28(9), 969-970. https://doi.org/10.3727/096504022X16414984936773
Abstract
Kallistatin has been recognized as an endogenous angiogenesis inhibitor and exerts pleiotropic effects in inhibiting tumor growth, migration, apoptosis, and inflammation. The purpose of the present study was to investigate the potential role and mechanisms of kallistatin in cervical cancer. We demonstrated that kallistatin
effectively inhibited cell proliferation and enhanced apoptosis in a dose-dependent manner. Additionally, kallistatin suppressed migration and invasion activities and markedly reduced the expression of matrix-degrading
metalloproteinases, progelatinase (MMP-2), MMP-9, and urokinase-type PA (uPA). Kallistatin reversed the
epithelial–mesenchymal transition (EMT) and caused the upregulation of epithelial markers such as E-cadherin
and inhibited mesenchymal markers such as N-cadherin and vimentin. Moreover, kallistatin led to a marked
decrease in the expression of vascular endothelial growth factor (VEGF) and HIF-1a. In a xenograft mouse
model, kallistatin treatment reduced tumor growth. Importantly, kallistatin strikingly impeded NF-kB activation by suppressing IkBk degradation and the level of phosphorylation of p65. Interestingly, similar to kallistatin, treatment with PDTC (an inhibitor of NF-kB) also attenuated cell invasion and migration. Taken together,
these findings suggest that kallistatin suppresses cervical cancer cell proliferation, migration, and EMT and
promotes cell apoptosis by blocking the NF-kB signaling pathway, suggesting that kallistatin may be a novel
therapeutic target for cervical cancer treatment.
Keywords
Cite This Article
Wang, T., Shi, F., Wang, J., Liu, Z., Su, J. (2020). Kallistatin Suppresses Cell Proliferation and Invasion and Promotes Apoptosis in Cervical Cancer Through Blocking NF-κB Signaling.
Oncology Research, 28(9), 969–970.