TY - EJOU AU - Li, Hui AU - Li, Han-Han AU - Chen, Qian AU - Wang, Yu-Yang AU - Fan, Chang-Chang AU - Duan, Yuan-Yuan AU - Huang, You AU - Zhang, Hui-Min AU - Li, Jia-Peng AU - Zhang, Xiao-Yu AU - Xiang, Yuan AU - Gu, Chao-Jiang AU - Wang, Li AU - Liao, Xing-Hua AU - Zhang, Tong-Cun TI - miR-142-5p Inhibits Cell Invasion and Migration by Targeting DNMT1 in Breast Cancer T2 - Oncology Research PY - 2020 VL - 28 IS - 9 SN - 1555-3906 AB - Abnormal cell proliferation caused by abnormal transcription regulation mechanism seems to be one of the reasons for the progression of breast cancer and also the pathological basis. MicroRNA-142-5p (miR-142-5p) is a low-expressed miRNA in breast cancer. The role of MKL-1’s regulation of DNMT1 in breast cancer cell proliferation and migration is still unclear. MKL-1 (myocardin related transcription factor A) can bind to the conserved cis-regulatory element CC (A/T) 6GG (called CarG box) in the promoter to regulate the transcription of miR-142-5p. The expressions of miR-142-5p and MKL-1 are positively correlated. In addition, it has been proved that DNMT1 is the target of miR-142-5p, which inhibits the expression of DNMT1 by targeting the 3¢-UTR of DNMT1, thereby forming a feedback loop and inhibiting the migration and proliferation of breast cancer. Our data provide important and novel insights into the MKL-1/miR-142-5p/DNMT1/maspin signaling pathway and may become a new idea for breast cancer diagnosis, treatment, and prognosis. KW - DNMT1; Maspin; miR-142-5p; MKL-1; Breast cancer DO - 10.3727/096504021X16274672547967