Open Access

ARTICLE

(−)-Epigallocatechin-3-Gallate Inhibits EBV Lytic Replication via Targeting LMP1-Mediated MAPK Signal Axes

Hongde Li^*†‡, Yueshuo Li^*†‡, Jianmin Hu^*†‡, Sufang Liu^§, Xiangjian Luo^*†‡¶, Min Tang^*†‡, Ann M. Bode^#, Zigang Dong^#**, Xinqi Liu^††, Weihua Liao^‡‡, Ya Cao^{*†‡¶ §§¶¶}

* Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University, Changsha, P.R. China
† Cancer Research Institute and School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, P.R. China
‡ Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Changsha, P.R. China
§ Division of Hematology, Institute of Molecular Hematology, the Second Xiangya Hospital, Central South University at Changsha, Changsha, P.R. China
¶ Molecular Imaging Research Center of Central South University, Changsha, P.R. China
# The Hormel Institute, University of Minnesota, Austin, MN, USA
** College of Medicine, Zhengzhou University, Zhengzhou, P.R. China
†† State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University at Tianjin, Tianjin, P.R. China
‡‡ Department of Radiology, Xiangya Hospital, Central South University at Changsha, Changsha, P.R. China
§§ Research Center for Technologies of Nucleic Acid Based Diagnostics and Therapeutics Hunan Province, Changsha, P.R. China
¶¶ National Joint Engineering Research Center for Genetic Diagnostics of Infectious Diseases and Cancer, Changsha, P.R. China