Open Access
ARTICLE
Microenvironment Analysis of Prognosis and Molecular Signature of Immune-Related Genes in Lung Adenocarcinoma
Bo Ling, Zuliang Huang, Suoyi Huang, Li Qian, Genliang Li, Qianli Tang
Youjiang Medical University for Nationalities, Baise, Guangxi, P.R. China
Oncology Research 2020, 28(6), 561-578. https://doi.org/10.3727/096504020X15907428281601
Abstract
There is growing evidence on the clinical significance of tumor microenvironment (TME) cells in predicting prognosis and therapeutic effects. However, cell interactions in tumor microenvironments have not been
thoroughly studied or systematically analyzed so far. In this study, 22 immune cell components in the lung
adenocarcinoma (LUAD) TME were analyzed using gene expression profile from The Cancer Genome Atlas
(TCGA) and Gene Expression Omnibus (GEO). The TME-based molecular subtypes of LUAD were defined
to evaluate further the relationship between molecular subtypes, prognosis, and clinical characteristics. A TME
risk score model was constructed by using the differentially expressed genes (DEGs) of molecular subtypes.
The relationship between the TME score and clinical characteristics and genomic mutations was compared to
identify the genes that have significant associations with the TME. The comprehensive analysis of the TME
characteristics may be helpful in revealing the response of LUAD patients to immunotherapy, providing a new
strategy for immunotherapy.
Keywords
Cite This Article
Ling, B., Huang, Z., Huang, S., Qian, L., Li, G. et al. (2020). Microenvironment Analysis of Prognosis and Molecular Signature of Immune-Related Genes in Lung Adenocarcinoma.
Oncology Research, 28(6), 561–578.