TY - EJOU AU - Maimaitiming, Adilijiang AU - Wusiman, Ailijiang AU - Aimudula, Abulajiang AU - Kuerban, Xuekelaiti AU - Su, Pengcheng TI - MicroRNA-152 Inhibits Cell Proliferation, Migration, and Invasion in Breast Cancer T2 - Oncology Research PY - 2020 VL - 28 IS - 1 SN - 1555-3906 AB - The aim of the present study was to investigate the roles of microRNA-152 (miR-152) in the initiation and progression of breast cancer. The expression level of miR-152 was detected in human breast cancer tissue and a panel of human breast cancer cell lines using qRT-PCR. Results found that miR-152 expression was significantly downregulated in breast cancer tissue samples compared to adjacent noncancerous tissues as well as in breast cancer cell lines. Overexpression of miR-152 significantly suppressed breast cancer cell proliferation, migration, and invasion. Luciferase reporter assay results found that ROCK1 is a direct and functional target gene of miR-152 in breast cancer. In addition, downexpression of ROCK1 could inhibit breast cancer cell proliferation, migration, and invasion. These findings indicate that miR-152 inhibited breast cancer growth and metastasis through negative regulation of ROCK1 expression. These data suggest that miR-152/ROCK1 pathway may be a useful therapeutic target for breast cancer treatment. KW - Breast cancer; MicroRNA-152; Growth; Metastasis; Therapy; Rho-associated protein kinase 1 (ROCK1) DO - 10.3727/096504019X15519249902838