Open Access

ARTICLE

MicroRNA-152 Inhibits Cell Proliferation, Migration, and Invasion in Breast Cancer

Adilijiang Maimaitiming^*, Ailijiang Wusiman^†, Abulajiang Aimudula^†, Xuekelaiti Kuerban^*, Pengcheng Su^*

* Department of Breast and Thyroid Surgery, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, P.R. China
† Department of Surgery, Hospital of Xinjiang Traditional Uyghur, Urumqi, P.R. China

Oncology Research 2020, 28(1), 13-19. https://doi.org/10.3727/096504019X15519249902838

Abstract

The aim of the present study was to investigate the roles of microRNA-152 (miR-152) in the initiation and progression of breast cancer. The expression level of miR-152 was detected in human breast cancer tissue and a panel of human breast cancer cell lines using qRT-PCR. Results found that miR-152 expression was significantly downregulated in breast cancer tissue samples compared to adjacent noncancerous tissues as well as in breast cancer cell lines. Overexpression of miR-152 significantly suppressed breast cancer cell proliferation, migration, and invasion. Luciferase reporter assay results found that ROCK1 is a direct and functional target gene of miR-152 in breast cancer. In addition, downexpression of ROCK1 could inhibit breast cancer cell proliferation, migration, and invasion. These findings indicate that miR-152 inhibited breast cancer growth and metastasis through negative regulation of ROCK1 expression. These data suggest that miR-152/ROCK1 pathway may be a useful therapeutic target for breast cancer treatment.

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Keywords

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