Open Access
ARTICLE
Kazuo Umezawa
Oncology Research, Vol.28, No.1, pp. 1-1, 2020, DOI:10.3727/096504020X15795276404798
Abstract This article has no abstract. More >
Open Access
ARTICLE
Xiangbin Tan*1, Zefei Liao†1, Shuangyou Zou*, Liangyun Ma†, Aimin Wang*
Oncology Research, Vol.28, No.1, pp. 3-11, 2020, DOI:10.3727/096504019X15509383469698
Abstract Vasohibin2 (VASH2), a proangiogenic factor, has been demonstrated to play an oncogenic role in some
common human cancers. However, the detailed function of VASH2 in non-small cell lung cancer (NSCLC) has
not previously been studied. In this study, we found that VASH2 was significantly upregulated in NSCLC tissues
and cell lines, and its increased expression was associated with NSCLC progression and poor prognosis of
patients. Knockdown of VASH2 markedly inhibited cell proliferation and P-glycoprotein expression in NSCLC
cells. Overexpression of VASH2 enhanced cell proliferation, P-glycoprotein expression, as well as doxorubicin
resistance in NSCLC cells. Moreover, the expression levels of VASH2… More >
Open Access
ARTICLE
Adilijiang Maimaitiming*, Ailijiang Wusiman†, Abulajiang Aimudula†, Xuekelaiti Kuerban*, Pengcheng Su*
Oncology Research, Vol.28, No.1, pp. 13-19, 2020, DOI:10.3727/096504019X15519249902838
Abstract The aim of the present study was to investigate the roles of microRNA-152 (miR-152) in the initiation and
progression of breast cancer. The expression level of miR-152 was detected in human breast cancer tissue and
a panel of human breast cancer cell lines using qRT-PCR. Results found that miR-152 expression was significantly downregulated in breast cancer tissue samples compared to adjacent noncancerous tissues as well as in
breast cancer cell lines. Overexpression of miR-152 significantly suppressed breast cancer cell proliferation,
migration, and invasion. Luciferase reporter assay results found that ROCK1 is a direct and functional target
gene of miR-152 in… More >
Open Access
ARTICLE
Zhong-xin Zhou*, Zu-ping Zhang†, Ze-zhang Tao*, Ting-zhao Tan‡
Oncology Research, Vol.28, No.1, pp. 21-31, 2020, DOI:10.3727/096504018X15213142076069
Abstract Laryngeal cancer, one of the most common head and neck malignancies, is an aggressive neoplasm. Increasing
evidence has demonstrated that microRNAs (miRNAs) exert important roles in oncogenesis and progression
of diverse types of human cancers. miR-632, a tumor-related miRNA, has been reported to be dysregulated
and implicated in human malignancies; however, its biological role in laryngeal carcinoma remains to be elucidated. The present study aimed at exploring the role of miR-632 in laryngeal cancer and clarifying the potential
molecular mechanisms involved. In the current study, miR-632 was found to be significantly upregulated
both in laryngeal cancer tissues and laryngeal cancer… More >
Open Access
ARTICLE
Annemarie E. M. Post*†, Johan Bussink*, Fred C. G. J. Sweep†, Paul N. Span*
Oncology Research, Vol.28, No.1, pp. 33-40, 2020, DOI:10.3727/096504019X15555794826018
Abstract Tamoxifen-induced radioresistance, reported in vitro, might pose a problem for patients who receive neoadjuvant tamoxifen treatment and subsequently receive radiotherapy after surgery. Previous studies suggested that
DNA damage repair or cell cycle genes are involved, and could therefore be targeted to preclude the occurrence
of cross-resistance. We aimed to characterize the observed cross-resistance by investigating gene expression
of DNA damage repair genes and cell cycle genes in estrogen receptor-positive MCF-7 breast cancer cells that
were cultured to tamoxifen resistance. RNA sequencing was performed, and expression of genes characteristic
for several DNA damage repair pathways was investigated, as well as expression… More >
Open Access
ARTICLE
Xiao-Na L*i, Hong Yang†, Tao Yang‡
Oncology Research, Vol.28, No.1, pp. 41-49, 2020, DOI:10.3727/096504019X15615433287579
Abstract In the present study, we investigated the role of miR-122 in hepatocarcinoma progression and explored the
mechanism. In hepatocarcinoma tissues and cells, we used qRT-PCR to validate the miR-122 expression level.
Next, we used colony formation by crystal violet staining assay to compare cell proliferation ability, and we
used scratch test or Transwell assay to compare cell migration or invasion ability. We then conducted bioinformatics or luciferase reporter gene assay to prove the regulation effect of miR-122 on lamin B2 (LMNB2),
and the biological function of LMNB2 was analyzed. We used nude mouse tumorigenicity assay to test the
inhibition effect… More >
Open Access
ARTICLE
Jing Li*†, Lian-mei Zhao‡, Cong Zhang‡, Meng Li§, Bo Gao†, Xu-hua Hu†, Jian Cao†, Gui-ying Wang†
Oncology Research, Vol.28, No.1, pp. 51-63, 2020, DOI:10.3727/096504019X15619783964700
Abstract Long noncoding RNAs (lncRNAs) participate in and regulate the biological process of colorectal cancer (CRC)
progression. Our previous research identified differentially expressed lncRNAs in 10 CRC tissues and 10
matched nontumor tissues by next-generation sequencing (NGS). In this study, we identified an lncRNA,
FEZF1 antisense RNA 1 (FEZF1-AS1), and further explored its function and mechanism in CRC. We verified
that FEZF1-AS1 is highly expressed in CRC tissues and cell lines. Through functional experiments, we found
that reduced levels of FEZF1-AS1 significantly suppressed CRC cell migration, invasion, and proliferation
and inhibited tumor growth in vivo. Mechanistically, we discovered that reduced levels… More >
Open Access
ARTICLE
Huasong Liu*1, Jun Zhang*1, Xiangyu Luo*, Min Zeng*, Liqiang Xu*, Qunxian Zhang*, Hua Liu*, Jialong Guo*, Lanlan Xu†
Oncology Research, Vol.28, No.1, pp. 65-73, 2020, DOI:10.3727/096504019X15656904013079
Abstract Emerging evidence has demonstrated that long noncoding RNAs (lncRNAs) mediate the development of
esophageal squamous cell carcinoma (ESCC) via various pathophysiological pathways. This study explored the
impact of the lncRNA FOXD2-AS1 on cisplatin resistance in ESCC and its possible mechanisms. Upregulation
of FOXD2-AS was detected in patients with ESCC and ESCC cells that are resistant to cisplatin. In an in vitro
assay, knockdown of FOXD2-AS1 noticeably inhibited cell invasion and growth, triggered cell death, and
repressed the stimulation of the Akt/mTOR axis in cisplatin-resistant ESCC cells (TE-1/DDP). Conversely,
the overexpression of FOXD2-AS1 remarkably increased cell invasion and growth, repressed cell… More >
Open Access
ARTICLE
Junhui Sun*1, Guanhui Zhou*1, Xiaoxi Xie†, Wenjiang Gu‡, Jing Huang§, Dedong Zhu¶, Wenhao Hu#, Qinming Hou**, Changsheng Shi††, Tiefeng Li‡‡ , Xin Zhang§§, Wenbin Ji¶¶, Shihong Ying§§,
Zhiyi Peng§§, Jian Zhou##, Zhihai Yu***, Jiansong Ji†††, Haijun Du‡‡‡, Xiaohua Guo§§§,
Jian Fang¶¶¶, Jun Han###, Huanhai Xu****, Zhichao Sun††††, Wenqiang Yu‡‡‡‡, Guoliang Shao§§§§,
Xia Wu¶¶¶¶ ,Hongjie Hu¶¶¶¶ , Ling Li#, Jiaping Zheng§§§§, Jun Luo§§§§, Yutang Chen§§§§,
Guohong Cao####, Tingyang Hu‡‡‡‡
Oncology Research, Vol.28, No.1, pp. 75-94, 2020, DOI:10.3727/096504019X15662966719585
Abstract The purpose of this study was to investigate the efficacy and safety of drug-eluting beads transarterial chemoembolization (DEB-TACE) treatment in Chinese hepatocellular carcinoma (HCC) patients and the prognostic
factors for treatment response as well as survival. A total of 275 HCC patients were included in this prospective study. Treatment response was assessed by modified Response Evaluation Criteria in Solid Tumors
(mRECIST), and progression-free survival (PFS) as well as overall survival (OS) were determined. Liver function and adverse events (AEs) were assessed before and after DEB-TACE operation. Complete response
(CR), partial response (PR), and objective response rate (ORR) were 22.9%, 60.7%,… More >
Open Access
ARTICLE
Xiao-hui Sun*, Wen-jie Fan†, Zong-jian An‡, Yong Sun‡
Oncology Research, Vol.28, No.1, pp. 95-102, 2020, DOI:10.3727/096504019X15742472027401
Abstract Long noncoding RNA CRNDE (CRNDE) recently emerged as a carcinogenic promoter in various cancers
including medulloblastoma. However, the functions and molecular mechanisms of CRNDE to the acquired
drug resistance of medulloblastoma are still unclear. The transcript levels of CRNDE were examined in four
medulloblastoma cell lines exposed to cisplatin treatment, and IC50 values were calculated. Effects of CRNDE
knockdown or miR-29c-3p overexpression on cell viability, colony formation, apoptosis, migration, and invasion were assessed using the CCK-8, colony formation assay, flow cytometry, and Transwell assays, respectively. RNA pulldown and RNA-binding protein immunoprecipitation (RIP) were performed to confirm the
molecular interactions between… More >
Open Access
ARTICLE
Jian Zhao*1, Xia Zhang†1, Xiaonan Cui*, Di Wang*, Bin Zhang*‡, Liying Ban*
Oncology Research, Vol.28, No.1, pp. 103-106, 2020, DOI:10.3727/096504019X15605078731913
Abstract Hand–foot syndrome (HFS) is the main side effect of capecitabine and affects the compression zones of the
body such as the palms and soles, causing numbness, paresthesias, skin swelling or erythema, scaling, chapping,
hard nodule-like blisters, and severe pain. Loss of fingerprints is also observed in some cases. Severe cases of
HFS are common in the review of clinical reports. However, loss of fingerprints has not received significant
attention. Two reported cases of loss of fingerprints in The New England Journal of Medicine and The BMJ
have drawn attention to this side effect of capecitabine. Loss of fingerprints has a… More >
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