Open Access
ARTICLE
High Blood miR-802 Is Associated With Poor Prognosis in HCC Patients by Regulating DNA Damage Response 1 (REDD1)-Mediated Function of T Cells
Chao Jiang*, Xueyan Liu†, Meng Wang*, Guoyue Lv*, Guangyi Wang*
* Department of Hepatobiliary Pancreatic Surgery, First Hospital of Jilin University, Changchun, P.R. China
† Department of Cardiology, China–Japan Union Hospital of Jilin University, Changchun, P.R. China
Oncology Research 2019, 27(9), 1025-1034. https://doi.org/10.3727/096504018X15456687424096
Abstract
miR-802 has been reported to be dysregulated in multiple tumors and contribute to tumor progression. However,
its role in HCC was still largely unknown. The aim of this study is to investigate the function and mechanism
of miR-802 in HCC progression. The results showed that miR-802 was upregulated in the peripheral blood
and tumor tissue of HCC patients, and high levels of blood miR-802 predicted poor prognosis. miR-802 had
no effect on the proliferation and migration of HCC cell lines. Interestingly, the levels of CD8/CD28 and
regulated in development and DNA damage response 1 (REDD1) were declined along with the upregulation
of miR-802 in vivo. Hence, it is speculated that miR-802 participated in the regulation of T-cell function in
HCC patients. Furthermore, we demonstrated that mir-802 directly targets REDD1 and inhibited its expression.
miR-802 increased the expression of programmed cell death protein 1 (PD-1) and decreased the expression of
interferon- (IFN- ) and CD8
+
CD28
+ T-cell number. In conclusion, miR-802 was involved in T-cell exhaustion
through posttranscriptionally suppressing REDD1, which might offer the suppressive effect of miR-802 on
HCC progression.
Keywords
Cite This Article
APA Style
Jiang, C., Liu, X., Wang, M., Lv, G., Wang, G. (2019). High blood mir-802 is associated with poor prognosis in HCC patients by regulating DNA damage response 1 (redd1)-mediated function of T cells. Oncology Research, 27(9), 1025-1034. https://doi.org/10.3727/096504018X15456687424096
Vancouver Style
Jiang C, Liu X, Wang M, Lv G, Wang G. High blood mir-802 is associated with poor prognosis in HCC patients by regulating DNA damage response 1 (redd1)-mediated function of T cells. Oncol Res. 2019;27(9):1025-1034 https://doi.org/10.3727/096504018X15456687424096
IEEE Style
C. Jiang, X. Liu, M. Wang, G. Lv, and G. Wang "High Blood miR-802 Is Associated With Poor Prognosis in HCC Patients by Regulating DNA Damage Response 1 (REDD1)-Mediated Function of T Cells," Oncol. Res., vol. 27, no. 9, pp. 1025-1034. 2019. https://doi.org/10.3727/096504018X15456687424096