Open Access
ARTICLE
Luteolin Suppresses Teratoma Cell Growth and Induces Cell Apoptosis via Inhibiting Bcl-2
Teng Liu*, Juan Xu†, Hong Li Yan‡, Feng Chun Cheng*, Xi Jie Liu*
* Department of Pediatric Surgery, Binzhou Medical University Hospital, Binzhou City, Shandong Province, P.R. China
† Pediatric Respiration and Intensive Care Unit, Binzhou Medical University Hospital, Shandong Province, P.R. China
‡ Electrocardiogram Room, Binzhou Medical University Hospital, Binzhou City, Shandong Province, P.R. China
Oncology Research 2019, 27(7), 773-778. https://doi.org/10.3727/096504018X15208986577685
Abstract
Luteolin, which is found in plant foods, has a range of therapeutic applications. In order to examine the potential roles of luteolin in ovarian teratocarcinoma, the human ovarian teratocarcinoma cell line PA-1 was selected
for functional experiments in vitro and in vivo. We demonstrated that luteolin inhibited the proliferation and
colony formation of PA-1 cells in vitro. The flow cytometry results suggested that luteolin induced apoptosis
of PA-1 cells in a dose-dependent manner. Immunofluorescence and qRT-PCR results showed that the expression of B-cell lymphoma-2 (Bcl-2) was decreased in luteolin-treated cells, whereas the expression of Bcl-2-
associated X (Bax) was increased compared with that in the control group. In addition, luteolin inhibited the
tumor growth of ovarian teratocarcinoma cells in a xenograft model. All the results suggested that luteolin
induced cell apoptosis and inhibited tumor growth of PA-1 cells.
Keywords
Cite This Article
Liu, T., Xu, J., Yan, H. L., Cheng, F. C., Liu, X. J. (2019). Luteolin Suppresses Teratoma Cell Growth and Induces Cell Apoptosis via Inhibiting Bcl-2.
Oncology Research, 27(7), 773–778.