Open Access

ARTICLE

Luteolin Suppresses Teratoma Cell Growth and Induces Cell Apoptosis via Inhibiting Bcl-2

Teng Liu^*, Juan Xu^†, Hong Li Yan^‡, Feng Chun Cheng^*, Xi Jie Liu^*

* Department of Pediatric Surgery, Binzhou Medical University Hospital, Binzhou City, Shandong Province, P.R. China
† Pediatric Respiration and Intensive Care Unit, Binzhou Medical University Hospital, Shandong Province, P.R. China
‡ Electrocardiogram Room, Binzhou Medical University Hospital, Binzhou City, Shandong Province, P.R. China

Oncology Research 2019, 27(7), 773-778. https://doi.org/10.3727/096504018X15208986577685

Abstract

Luteolin, which is found in plant foods, has a range of therapeutic applications. In order to examine the potential roles of luteolin in ovarian teratocarcinoma, the human ovarian teratocarcinoma cell line PA-1 was selected for functional experiments in vitro and in vivo. We demonstrated that luteolin inhibited the proliferation and colony formation of PA-1 cells in vitro. The flow cytometry results suggested that luteolin induced apoptosis of PA-1 cells in a dose-dependent manner. Immunofluorescence and qRT-PCR results showed that the expression of B-cell lymphoma-2 (Bcl-2) was decreased in luteolin-treated cells, whereas the expression of Bcl-2- associated X (Bax) was increased compared with that in the control group. In addition, luteolin inhibited the tumor growth of ovarian teratocarcinoma cells in a xenograft model. All the results suggested that luteolin induced cell apoptosis and inhibited tumor growth of PA-1 cells.

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