TY - EJOU
AU - Zhang, Kai
AU - Chen, Huajun
AU - Wang, Ye
AU - Yang, Lin
AU - Zhou, Chengzhi
AU - Yin, Weiqiang
AU - Wang, Guangsuo
AU - Mao, Xinru
AU - Xiang, Jianxing
AU - Li, Bing
AU - Zhang, Tengfei
AU - Fei, Shihong
TI - Clinical Characteristics and Molecular Patterns of RET-Rearranged Lung Cancer in Chinese Patients
T2 - Oncology Research
PY - 2019
VL - 27
IS - 5
SN - 1555-3906
AB - RET rearrangement has been proven as an oncogenic driver in patients with lung cancer. However, the prevalence, clinical characteristics, molecular features, and therapeutic options in RET-rearranged patients remain
unclear, especially in Chinese lung cancer patients. We retrospectively collected 6,125 Chinese lung cancer
patients who have been profiled using next-generation sequencing (NGS). The clinical demographics and
molecular features of RET rearrangement-positive patients were analyzed. RET rearrangements were identified in 84 patients with a proportion of 1.4% in our cohort. The median age at diagnosis was 58 years, and it
mainly occurred in females with adenocarcinoma histology. KIF5B-RET was the most frequent fusion type
and accounted for 53.8% (57/106) of all RET fusions identified, with K15-R12 as the most frequent variant (71.9%). Among 47 RET+
patients profiled with larger panels, 72.3% (34/47) harbored concurrent alterations. TP53 ranked as the most common concurrent alteration, and concomitant EGFR oncogenic alterations
were identified in seven patients. Moreover, an adenocarcinoma patient harboring concurrent RET fusion and
EGFR L858R responded to combinatorial treatment of cabozantinib and osimertinib, with a progression-free
survival of 5 months. Our study improved knowledge of clinical characteristics and molecular features of
RET-rearranged lung cancers in China. It might be helpful to guide clinicians for more effective personalized
diagnostic and therapeutic approaches.
KW - RET rearrangement; Lung cancer; Adenocarcinoma; Clinical characteristics; Concurrent gene alteration
DO - 10.3727/096504018X15344979253618