Open Access
ARTICLE
Chijiang Gu*, Mingyuan Zhang*, Weiliang Sun*, Changzheng Dong†
Oncology Research, Vol.27, No.5, pp. 515-524, 2019, DOI:10.3727/096504018X15166183598572
Abstract Colorectal cancer (CRC) is a common clinical cancer that remains incurable in most cases. miRNAs are
reported to play a part in the development of various tumors. In the present study, we found that miR-324-5p
was downregulated in CRC cells, while ELAV (embryonic lethal, abnormal vision, Drosophila)-like protein
1 (ELAVL1) showed a higher expression. miR-324-5p transfection significantly inhibited the proliferation
as well as invasion in both SW620 and SW480 cells. miR-324-5p mimic transfection markedly decreased
the expression of ELAVL1. Luciferase reporter gene assay confirmed that ELAVL1 is a direct target of miR-
324-5p. Furthermore, cancer invasion factors uPA, uPAR, and… More >
Open Access
ARTICLE
Ting Yu*1, Lei Li†1, Wenyan Liu*, Bailiu Ya*, Hongju Cheng*, Qing Xin*
Oncology Research, Vol.27, No.5, pp. 525-532, 2019, DOI:10.3727/096504018X15179668157803
Abstract Hypoxia-induced chemoresistance is a major obstacle in the development of effective cancer therapy. In our
study, the reversal abilities of NADPH oxidase 4 (NOX4) silence on hypoxia resistance and the potential
mechanism were investigated. Our data showed that the expression of NOX4 was upregulated in human neuroblastoma cells SH-SY5Y under hypoxia condition time dependently. Knockdown of NOX4 expression by
siRNA inhibited glycolysis induced by hypoxia through decreasing the expression of glycolysis-related proteins (HIF-1 , LDHA, and PDK1), decreasing glucose uptake, lactate production, and ROS production, while
increasing mitochondria membrane potential. Moreover, NOX4 silence inhibited cell growth under hypoxia
condition through… More >
Open Access
ARTICLE
Xiaoying Han*1, Jing Yang†1, Dong Li‡, Zewei Guo§
Oncology Research, Vol.27, No.5, pp. 533-540, 2019, DOI:10.3727/096504018X15199489058224
Abstract Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated mortality worldwide. Although
the mechanisms of HCC progression are not well understood, recent studies demonstrated the potential contribution of uric acid transporter SLC2A9 to tumor suppression. However, the roles and underlying mechanisms are still unknown. We aimed to study the roles and mechanisms of SLC2A9 in HCC. The present study
showed that SLC2A9 expression was decreased in human HCC tissues and cell lines. In addition, overexpression of SLC2A9 inhibited HCC cell proliferation. SCL2A9 induced HCC cell apoptosis by inhibiting the
expression of caspase 3. Our study also revealed that upregulation… More >
Open Access
ARTICLE WITHDRAWN
Wang, Kecheng1, Zhang, Meng2, Wang, Cong2, Ning, Xiaofei1
Oncology Research, Vol.27, No.5, pp. 541-549, 2019, DOI:10.3727/096504018X15234931503876
Abstract THIS ARTICLE WAS WITHDRAWN BY THE PUBLISHERS IN OCTOBER 2020. More >
Open Access
ARTICLE
Yuma Nonomiya*, Takashi Yokokawa†, Kazuyoshi Kawakami†, Kazuo Kobayashi†, Takeshi Aoyama†,
Tomomi Takiguchi†, Takahito Sugisaki†, Kenichi Suzuki†, Mitsukuni Suenaga‡, Takeru Wakatsuki‡,
Kensei Yamaguchi‡, Yoshikazu Sugimoto*, Toshihiro Hama†
Oncology Research, Vol.27, No.5, pp. 551-556, 2019, DOI:10.3727/096504018X15291727589740
Abstract Regorafenib is a multikinase inhibitor for the treatment of metastatic colorectal cancer. Regorafenib-induced
hand–foot skin reaction (HFSR) is a common side effect during treatment. The reported frequency of HFSR
was 80% (grade 3: 28%) in the Japanese subpopulation in the CORRECT trial; however, more detailed data
regarding HFSR in terms of onset and sites of susceptibility are unclear. Additionally, the risk factors for
regorafenib-induced severe HFSR are unknown. The aim of this study was to compare HFSR between the
hands and feet and identify preexisting risk factors for severe HFSR in Japanese patients receiving regorafenib.
We retrospectively examined the onset… More >
Open Access
ARTICLE
Liping Xue*1, Bin Lu†1, Bibo Gao‡, Yangyang Shi‡, Jingqi Xu‡, Rui Yang‡, Bo Xu‡, Peng Ding‡
Oncology Research, Vol.27, No.5, pp. 557-564, 2019, DOI:10.3727/096504018X15264647024196
Abstract Because of the characteristics of high invasiveness, relapse, and poor prognosis, the management of malignant
gliomas has always been a great challenge. Nod-like receptor (NLR) family pyrin domain containing 3 (NLRP3) is
a crucial component of the NLRP3 inflammasome, a multiprotein complex that can trigger caspase 1/interleukin-1
(IL-1)-mediated inflammatory response once activated and participates in the pathogeny of diverse inflammatory
diseases as well as cancers. We examined the function of NLRP3 in the development of glioma. Glioma cells were
treated with NLRP3 interference or overexpression vectors, recombinant IL-1 , IL-1 antibody, and NF- B inhibitor. Cell proliferation and invasion were… More >
Open Access
ARTICLE
Yaohong Liu, Wensou Huang, Mingji He, Hui Lian, Yongjian Guo, Jingjun Huang, Jingwen Zhou, Kangshun Zhu
Oncology Research, Vol.27, No.5, pp. 565-573, 2019, DOI:10.3727/096504018X15313896322888
Abstract This study aimed to investigate the efficacy and safety of drug-eluting beads transarterial chemoembolization
(DEB-TACE) treatment in Barcelona Clinic Liver Cancer (BCLC) stage C liver cancer patients. In 39 patients
with BCLC stage C liver cancer, after the first cycle of DEB-TACE, 2 (5.1%) and 24 (61.5%) patients achieved
complete response (CR) and partial response (PR) to give an overall objective response rate (ORR) of 66.7%.
With respect to the second cycle of therapy, the ORR was higher in patients receiving DEB-TACE compared
with those receiving cTACE (57.1% vs. 11.1%). After the first cycle of DEB-TACE treatment, the percentages
of… More >
Open Access
ARTICLE
Kai Zhang*, Huajun Chen†, Ye Wang‡, Lin Yang§, Chengzhi Zhou¶, Weiqiang Yin#, Guangsuo Wang§,
Xinru Mao**, Jianxing Xiang**, Bing Li**, Tengfei Zhang**, Shihong Fei*
Oncology Research, Vol.27, No.5, pp. 575-582, 2019, DOI:10.3727/096504018X15344979253618
Abstract RET rearrangement has been proven as an oncogenic driver in patients with lung cancer. However, the prevalence, clinical characteristics, molecular features, and therapeutic options in RET-rearranged patients remain
unclear, especially in Chinese lung cancer patients. We retrospectively collected 6,125 Chinese lung cancer
patients who have been profiled using next-generation sequencing (NGS). The clinical demographics and
molecular features of RET rearrangement-positive patients were analyzed. RET rearrangements were identified in 84 patients with a proportion of 1.4% in our cohort. The median age at diagnosis was 58 years, and it
mainly occurred in females with adenocarcinoma histology. KIF5B-RET was the most frequent… More >
Open Access
ARTICLE
Ping Wen*, Sheng-Duo Chen*, Jia-Rui Wang†, Ying-He Zeng*
Oncology Research, Vol.27, No.5, pp. 583-592, 2019, DOI:10.3727/096504018X15368325811545
Abstract This study evaluated the difference in treatment response and survival profiles between drug-eluting bead
transarterial chemoembolization (DEB-TACE) and conventional transarterial chemoembolization (cTACE)
treatments in Chinese hepatocellular carcinoma (HCC) patients. A total of 120 HCC patients were consecutively enrolled in this prospective cohort study, which showed that DEB-TACE achieved higher complete
response (CR) (30.8%) compared with cTACE (7.4%) with no difference in overall response rate (ORR) for
patients treated with DEB-TACE and cTACE (80.8% vs. 73.5%). In addition, DEB-TACE was associated with
a lower rate of progressive disease (PD) compared with cTACE (1.9% vs. 11.8%). With respect to survival,
patients in… More >
Open Access
ARTICLE
Jun Shan Ruan*†, Huan Zhou*, Lin Yang‡, Ling Wang*, Zong Sheng Jiang§, Hong Sun*, Shao Ming Wang*†
Oncology Research, Vol.27, No.5, pp. 593-600, 2019, DOI:10.3727/096504017X15051723858706
Abstract Transforming growth factor- 1 (TGF- 1)-induced epithelial–mesenchymal transition (EMT) of non-small cell
lung cancer (NSCLC) may contribute to tumor metastasis. TGF- 1-induced EMT in H1975 cells (a human
NSCLC cell line) resulted in the adoption of mesenchymal responses that were predominantly mediated via
the TGF- 1–integrin signaling pathway. Ursolic acid has been previously reported to inhibit tumor growth and
metastasis in several cancers. However, whether ursolic acid can attenuate TGF- 1-induced EMT in H1975
cells and its underlying mechanisms remain unknown. In this study, ursolic acid significantly attenuated the
TGF- 1-induced decrease in E-cadherin level and elevated the level of… More >
Open Access
ARTICLE
Jiandong Guo, Huihua You, Dong Li
Oncology Research, Vol.27, No.5, pp. 601-611, 2019, DOI:10.3727/096504018X15399945637736
Abstract Baicalein, an active ingredient separated from Astragalus membranaceus, has shown its anticancer ability in
various cancers. However, its effect on nasopharyngeal carcinoma has not been explored yet. The present study
aimed to investigate the effect of baicalein on the growth, proliferation, apoptosis, and cell cycle of human
nasopharyngeal carcinoma cells, as well as transplanted nude mouse xenograft. The results showed that baicalein inhibited the growth and proliferation of CNE1 and CNE2 cells in a time- and concentration-dependent
manner. It also caused a significant increase in the number of cells in the G0/G1 phase and a decrease in the
G2/M phase,… More >
Open Access
ARTICLE
Hong Ye*, Qing Yang†, Shujie Qi*, Hairong Li‡
Oncology Research, Vol.27, No.5, pp. 613-621, 2019, DOI:10.3727/096504018X15410353669149
Abstract Hepatocellular carcinoma (HCC) has high morbidity and mortality rates, and the number of new cases and
deaths from liver cancer are increasing. However, the details of the regulation in HCC remain largely unknown.
Plant homeodomain finger protein 8 (PHF8) is a JmjC domain-containing protein. Recently, PHF8 was reported
to participate in several types of cancer. However, the biological function and clinical significance of PHF8 in
HCC remain unknown. In this study, we investigate the role of PHF8 in HCC growth and metastasis. We used
bioinformatics analysis and identified the differentially expressed PHF8 in primary HCC and metastasis HCC.
Immunohistochemistry analysis… More >
Open Access
ARTICLE
Wanjun Yu*, Weidong Peng*, Hanyun Sha†, Jipeng Li‡
Oncology Research, Vol.27, No.5, pp. 623-628, 2019, DOI:10.3727/096504018X15420734828058
Abstract Circular RNAs (circRNAs) represent a new class of noncoding RNAs that is involved in the development
of cancer. However, little is known about their role in chemoresistance. In the present study, we found that
hsa_circ_0003998 expression levels in lung adenocarcinoma (LAD) tissues and docetaxel-resistant cell lines
(A549/DTX and H1299/DTX) were upregulated. Knockdown of hsa_circ_0003998 decreased chemoresistance, inhibited proliferation, and enhanced apoptosis in docetaxel-resistant LAD cells. Moreover, by using
bioinformatics and luciferase reporter assays, we found that miR-326 was a direct target of hsa_circ_0003998.
Functional analysis revealed that miR-326 mediated the effect of hsa_circ_0003998 on chemosensitivity. Our
findings provide a molecular… More >
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