Open Access

REVIEW

The Biological Function of Hepatitis B Virus X Protein in Hepatocellular Carcinoma

Qiaodong Xu¹, Songgang Gu¹, Jiahong Liang, Zhihua Lin, Shaodong Zheng, Jiang Yan

Department of Biliary-Pancreatic Minimally Invasive Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, P.R. China

Oncology Research 2019, 27(4), 509-514. https://doi.org/10.3727/096504018X15278771272963

Abstract

Hepatocellular carcinoma (HCC) is one of the major malignant tumors that lead to death. Chronic hepatitis B virus infection is an important risk factor for HCC initiation. HBx protein, encoded by the HBV X gene, is a significant factor that promotes HBV-related HCC, although the exact molecular mechanism remains unclear. This article summarizes the pathological roles and related mechanisms of HBx in HCC. HBx plays a carcinogenic role by promoting cell proliferation, metastasis, and angiogenesis and inhibiting apoptosis in HCC. A detailed study of the biological functions of HBx will help to elucidate the mechanism of hepatocarcinogenesis and lead to the development of novel therapeutic targets for the treatment of HBV-related HCC.

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Keywords

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