Open Access
ARTICLE
Efficacy Evaluation of Imatinib for the Treatment of Melanoma: Evidence From a Retrospective Study
Xiaoting Wei, Lili Mao, Zhihong Chi, Xinan Sheng, Chuanliang Cui, Yan Kong, Jie Dai, Xuan Wang,
Siming Li, Bixia Tang, Bin Lian, Xieqiao Yan, Xue Bai, Li Zhou, Jun Guo, Lu Si
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing),
Department of Renal Cancer and Melanoma, Peking University Cancer Hospital & Institute, Beijing, P.R. China
Oncology Research 2019, 27(4), 495-501. https://doi.org/10.3727/096504018X15331163433914
Abstract
Melanoma is an aggressive malignancy with a poor prognosis. Current studies show that imatinib treatment
is a promising approach in treating advanced melanoma patients harboring
c-Kit mutations or amplifications.
We retrospectively analyzed the clinical medical records of 78 patients with metastatic melanoma harboring
c-Kit mutations or amplifications. These patients were treated with imatinib at a dose of 400 mg/day continuously unless intolerable toxicities or disease progression occurred. Endpoints for exploration included overall
survival (OS), progression-free survival (PFS), objective response rate (ORR), and disease of control rate
(DCR). The median OS and PFS of all patients were 13.1 and 4.2 months, respectively. ORR and DCR were
21.8% and 60.3%, respectively. The survival time of patients who achieved partial response or stable disease
was significantly superior to those with disease progression. Cox regression analysis showed that patients with
M1c stage, subtype of cutaneous melanoma, or elevated LDH level (>upper limit of normal) had higher hazard
ratios for overall survival. Our study, combined with those studies targeting patients with a
c-Kit alteration,
validates the role of imatinib as an important and promising therapeutic agent in the treatment of patients with
advanced melanoma.
Keywords
Cite This Article
Wei, X., Mao, L., Chi, Z., Sheng, X., Cui, C. et al. (2019). Efficacy Evaluation of Imatinib for the Treatment of Melanoma: Evidence From a Retrospective Study.
Oncology Research, 27(4), 495–501.