Open Access
ARTICLE
TRIM14 Promotes Breast Cancer Cell Proliferation by Inhibiting Apoptosis
Gaowu Hu, Wei Pen, Ming Wang
Department of General Surgery, Shanghai Traditional Chinese Medicine-Integrated Hospital, Shanghai, P.R. China
Oncology Research 2019, 27(4), 439-447. https://doi.org/10.3727/096504018X15214994641786
Abstract
Tripartite motif-containing 14 (TRIM14) is abnormally expressed in several human cancers. However, the
function and expression of TRIM14 in human breast cancer are still largely unknown. To understand the biological function of TRIM14 in breast cancer, we measured the expression level of TRIM14. Cell proliferation
and cell apoptosis were measured after TRIM14 overexpression or knockdown. Upregulation of TRIM14 was
found in human breast cancer specimens and cell lines. Reduction of TRIM14 inhibited cell proliferation but
increased cell apoptosis in the BT474 and MDA-MB-231 cell lines. Further study showed that knockdown of
TRIM14 upregulated the expression of BAX while downregulating the expression of BCL2. In addition, the
expression of SHP-1 was increased, and the phosphorylation of STAT3 (p-STAT3) was inhibited. Conversely,
overexpression of TRIM14 had the opposite effects. Additionally, cryptotanshinone, a STAT3 inhibitor, inhibited cell proliferation but increased cell apoptosis in the BT474 and MDA-MB-231 cell lines. In conclusion,
TRIM14 may act as an oncogene in human breast cancer and may be a novel strategy for human breast cancer.
Keywords
Cite This Article
APA Style
Hu, G., Pen, W., Wang, M. (2019). TRIM14 promotes breast cancer cell proliferation by inhibiting apoptosis. Oncology Research, 27(4), 439-447. https://doi.org/10.3727/096504018X15214994641786
Vancouver Style
Hu G, Pen W, Wang M. TRIM14 promotes breast cancer cell proliferation by inhibiting apoptosis. Oncol Res. 2019;27(4):439-447 https://doi.org/10.3727/096504018X15214994641786
IEEE Style
G. Hu, W. Pen, and M. Wang "TRIM14 Promotes Breast Cancer Cell Proliferation by Inhibiting Apoptosis," Oncol. Res., vol. 27, no. 4, pp. 439-447. 2019. https://doi.org/10.3727/096504018X15214994641786