Table of Content

Open AccessOpen Access


CD47 Promotes Human Glioblastoma Invasion Through Activation of the PI3K/Akt Pathway

Xuejian Liu*1, Xia Wu*1, Yanming Wang, Yuhua Li*, Xiangli Chen*, Wenchuan Yang*, Lihua Jiang*

* Department of Oncology, Linyi Third People’s Hospital, Linyi, Shandong, P.R. China
† Department of Radiotherapy, Jinan Military Region General Hospital, Jinan, Shandong, P.R. China

Oncology Research 2019, 27(4), 415-422.


Cluster of differentiation 47 (CD47) overexpression is common in various malignancies. This study investigated whether CD47 promotes human glioblastoma invasion and, if so, the underlying mechanisms involved. CD47 expression was found to be stronger in tissues of patients with glioblastoma and in various cancer cell lines than in normal controls. CD47 downregulation via siRNA suppressed invasion in vitro, whereas CD47 overexpression through plasmid transfection exerted the opposite effect. However, overexpression or knocking down of CD47 had no effect on cell proliferation. Moreover, CD47 expression was related to Akt phosphorylation at the cellular molecular level. Suppression of Akt with a specific inhibitor impaired the invasion ability of CD47-overexpressing cells, indicating that stimulation of the PI3K/Akt pathway served as the downstream regulator of CD47-triggered invasion. These results suggest that CD47 might be a useful predictor of poor prognosis and metastasis and a potential target for treating glioblastomas.


Cite This Article

Liu, X., Wu, X., Wang, Y., Li, Y., Chen, X. et al. (2019). CD47 Promotes Human Glioblastoma Invasion Through Activation of the PI3K/Akt Pathway. Oncology Research, 27(4), 415–422.

This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • 287


  • 195


  • 0


Share Link