Open Access

ARTICLE

Overexpression of Pyruvate Dehydrogenase E1a Subunit Inhibits Warburg Effect and Induces Cell Apoptosis Through Mitochondria-Mediated Pathway in Hepatocellular Carcinoma

Jihong Sun^*†1, Jingjing Li^†1, Zhixian Guo^†, Lu Sun^†‡, Chenghui Juan^§, Yubing Zhou^¶, Hongli Gu^†, Yan Yu^†, Qiuyue Hu^†, Quancheng’ Kan^¶, Zujiang Yu^†

* Department of Internal Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China
† Department of Infectious Disease, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China
‡ Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China
§ Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China
¶ Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China