Open Access
ARTICLE
Xiaofei Ning*, Cong Wang†, Meng Zhang†, Kecheng Wang*
Oncology Research, Vol.27, No.4, pp. 399-406, 2019, DOI:10.3727/096504018X15179675206495
Abstract Colon cancer is one of the most common cancers in the world. Epithelial-to-mesenchymal transition (EMT)
is a crucial step in tumor progression and is also involved in the acquisition of stem cell-like properties. Some
miRNAs have been shown to function as either tumor suppressors or oncogenes in colon cancer. Here we
investigated the role of miR-147 in the regulation of the stem cell-like traits of colon cancer cells. We observed
that miR-147 was downregulated in several colon cancer cell lines, and overexpressed miR-147 decreased
the expression of cancer stem cell (CSC) markers OCT4, SOX2, and NANOG in the colon cancer… More >
Open Access
ARTICLE
Jihong Sun*†1, Jingjing Li†1, Zhixian Guo†, Lu Sun†‡, Chenghui Juan§, Yubing Zhou¶, Hongli Gu†, Yan Yu†, Qiuyue Hu†, Quancheng’ Kan¶, Zujiang Yu†
Oncology Research, Vol.27, No.4, pp. 407-417, 2019, DOI:10.3727/096504018X15180451872087
Abstract Most cancers rely disproportionately on glycolysis for energy even in the presence of an adequate oxygen
supply, a condition known as “aerobic glycolysis,” or the “Warburg effect.” Pyruvate dehydrogenase E1 subunit (PDHA1) is one of the main factors for the metabolic switch from oxidative phosphorylation (OXPHOS)
to aerobic glycolysis and has been suggested to be closely associated with tumorigenesis. Here we observed
that the PDHA1 protein was reduced in hepatocellular carcinoma (HCC) specimens by immunohistochemistry
and Western blot, which was significantly associated with poor overall survival. To further analyze the function of PDHA1 in cancer cells, PDHA1 was upregulated in… More >
Open Access
ARTICLE
Xuejian Liu*1, Xia Wu*1, Yanming Wang†, Yuhua Li*, Xiangli Chen*, Wenchuan Yang*, Lihua Jiang*
Oncology Research, Vol.27, No.4, pp. 415-422, 2019, DOI:10.3727/096504018X15155538502359
Abstract Cluster of differentiation 47 (CD47) overexpression is common in various malignancies. This study investigated whether CD47 promotes human glioblastoma invasion and, if so, the underlying mechanisms involved.
CD47 expression was found to be stronger in tissues of patients with glioblastoma and in various cancer cell
lines than in normal controls. CD47 downregulation via siRNA suppressed invasion in vitro, whereas CD47
overexpression through plasmid transfection exerted the opposite effect. However, overexpression or knocking
down of CD47 had no effect on cell proliferation. Moreover, CD47 expression was related to Akt phosphorylation at the cellular molecular level. Suppression of Akt with a specific… More >
Open Access
ARTICLE
Hai-Tao Li, Dao-Yong Dong, Qiang Liu, Yi-Qin Xu, Langbo Chen
Oncology Research, Vol.27, No.4, pp. 423-429, 2019, DOI:10.3727/096504017X15030178624579
Abstract LACTB, a mitochondrial protein, was ubiquitously expressed in different mammalian tissues, such as liver,
heart, and skeletal muscle. It has been shown that LACTB is downexpressed in breast cancers, and it suppresses the proliferation and promotes the apoptosis of breast cancers. However, its role in the progression
and prognosis of glioma remains unknown. In this study, we analyzed the clinicopathological features and
outcomes of LACTB expression in 98 glioma patients and investigated the effects of LACTB overexpression
on the proliferation, invasion, and angiogenesis of glioma cells in vitro. We observed a significant decrease in
LACTB expression in glioma, and downexpression… More >
Open Access
ARTICLE
Xin Chen*, Mingzhe Li†, Hongwei Zhou*, Li Zhang*
Oncology Research, Vol.27, No.4, pp. 431-437, 2019, DOI:10.3727/096504018X15201058168730
Abstract MicroRNA-132 (miR-132) has been demonstrated to be a tumor suppressor in several types of tumors. However,
the expression and the role of miR-132 in human thyroid cancer are still poorly understood. The aim of the
present study was to examine the potential roles and molecular mechanism of miR-132 in thyroid cancer. We
found that miR-132 expression levels were significantly downregulated in thyroid cancer tissues and cell lines.
Function assays showed that overexpression of miR-132 in TPC1 cells inhibited cell proliferation, migration,
and invasion. Forkhead box protein A1 (FOXA1) was identified as a direct target of miR-132 in thyroid cancer
cells.… More >
Open Access
ARTICLE
Gaowu Hu, Wei Pen, Ming Wang
Oncology Research, Vol.27, No.4, pp. 439-447, 2019, DOI:10.3727/096504018X15214994641786
Abstract Tripartite motif-containing 14 (TRIM14) is abnormally expressed in several human cancers. However, the
function and expression of TRIM14 in human breast cancer are still largely unknown. To understand the biological function of TRIM14 in breast cancer, we measured the expression level of TRIM14. Cell proliferation
and cell apoptosis were measured after TRIM14 overexpression or knockdown. Upregulation of TRIM14 was
found in human breast cancer specimens and cell lines. Reduction of TRIM14 inhibited cell proliferation but
increased cell apoptosis in the BT474 and MDA-MB-231 cell lines. Further study showed that knockdown of
TRIM14 upregulated the expression of BAX while downregulating the… More >
Open Access
ARTICLE
Guoyun Li, Wei Zhang, Li Gong, Xiaoping Huang
Oncology Research, Vol.27, No.4, pp. 449-458, 2019, DOI:10.3727/096504017X15016337254623
Abstract MicroRNAs, a class of endogenous noncoding RNAs, regulate gene expression at the posttranscriptional level
and thus take part in multiple biological processes. An increasing number of miRNAs have been found to be
dysregulated in hepatocellular carcinoma (HCC) and are involved in liver tumorigenesis. In this study, miR-
125a-5p was found to be obviously downregulated much more in hepatitis B virus (HBV)-related HCC. To
investigate the effects of miR-125a-5p, miR-125a-5p was overexpressed in HepG2.2.15 and HepG3X cells.
The findings have indicated that overexpression of miR-125a-5p dramatically inhibited cell proliferation and
induced cell apoptosis. Furthermore, overexpression of miR-125a-5p could significantly decrease the… More >
Open Access
ARTICLE
Liang Wu, Yuefeng Li, Jingye Li, Deliang Ma
Oncology Research, Vol.27, No.4, pp. 459-467, 2019, DOI:10.3727/096504018X15193500663936
Abstract A large number of microRNAs (miRNAs) have been previously demonstrated to be dysregulated in breast
cancer (BC), and alterations in miRNA expression may affect the initiation and progression of BC. This
study showed that miR-664 expression was obviously reduced in BC tissues and cell lines. Resumption
of the expression of miR-664 attenuated the proliferation and invasion of BC cells. The molecular mechanisms underlying the inhibitory effects of BC cell proliferation and invasion by miR-664 were also studied.
Insulin receptor substrate 1 (IRS1) was identified as a novel and direct target of miR-664. In addition, siRNAmediated silencing of IRS1 expression mimicked… More >
Open Access
ARTICLE
Takashi Saito*†, Atsuo Okamura‡, Junichiro Inoue†, Daisuke Makiura†, Hisayo Doi§, Kimikazu Yakushijin¶, Hiroshi Matsuoka¶, Yoshitada Sakai†#, Rei Ono*
Oncology Research, Vol.27, No.4, pp. 469-474, 2019, DOI:10.3727/096504018X15267574931782
Abstract Chemotherapy-induced peripheral neuropathy (CIPN) frequently occurs in lymphoma patients receiving
R-CHOP, a drug combination therapy. Although severe CIPN may lead to reduction and/or discontinuation
of the medication, predictive factors of CIPN have not been investigated sufficiently to date. We performed
a retrospective exploratory research to determine associations between prevalence of severe CIPN and sociodemographic data, health characteristics, and medical conditions such as anemia at initial diagnosis. Forty
patients (indolent lymphoma, n=9; diffuse large B-cell lymphoma; n=31) received R-CHOP therapy from
September 2009 to July 2014. The median age of patients was 58 years (range=27–76 years). Statistical analyses were applied to… More >
Open Access
ARTICLE
Jia Liu*, Ying Zhang†, Shulan Sun‡, Guirong Zhang‡, Ke Jiang,§ Peixin Sun*, Ye Zhang*, Bing Yao*, Rui Sui*, Yi Chen*, Xu Guo*, Tao Tang*, Ji Shi*, Haiyang Liang*, Haozhe Piao*
Oncology Research, Vol.27, No.4, pp. 475-486, 2019, DOI:10.3727/096504018X15270916676926
Abstract Glioma is the most common malignant tumor of the central nervous system, and it is characterized by high
relapse and fatality rates and poor prognosis. Bufalin is one of the main ingredients of Chan-su, a traditional
Chinese medicine (TCM) extracted from toad venom. Previous studies revealed that bufalin exerted inhibitory
effects on a variety of tumor cells. To demonstrate the inhibitory effect of bufalin on glioma cells and glioma
stem-like cells (GSCs) and discuss the underlying mechanism, the proliferation of glioma cells was detected by
MTT and colony formation assays following treatment with bufalin. In addition, we investigated whether bufalin… More >
Open Access
ARTICLE
Lu Guo*, Duankai Chen†, Xing Yin‡, Qingfeng Shu†
Oncology Research, Vol.27, No.4, pp. 487-494, 2019, DOI:10.3727/096504018X15323394008784
Abstract GSK-3 is a versatile protein kinase participating in many reactions. Currently, there is insufficient
understanding of its influence on breast cancer (BC). In order to explore its influence on migration and
invasion in BC, we investigated its expression in BC cell lines using qRT-PCR and Western blot (WB).
Immunohistochemistry (IHC) was used to examine the potential of GSK-3 to predict clinical outcome in
BC patients. GSK-3 knockdown was achieved using an shRNA plasmid vector in T47D cells. Our research
explored the biological reactions and downstream pathways involved. We found excessive GSK-3 expression in BC tissues, which was correlated with worse… More >
Open Access
ARTICLE
Xiaoting Wei, Lili Mao, Zhihong Chi, Xinan Sheng, Chuanliang Cui, Yan Kong, Jie Dai, Xuan Wang,
Siming Li, Bixia Tang, Bin Lian, Xieqiao Yan, Xue Bai, Li Zhou, Jun Guo, Lu Si
Oncology Research, Vol.27, No.4, pp. 495-501, 2019, DOI:10.3727/096504018X15331163433914
Abstract Melanoma is an aggressive malignancy with a poor prognosis. Current studies show that imatinib treatment
is a promising approach in treating advanced melanoma patients harboring c-Kit mutations or amplifications.
We retrospectively analyzed the clinical medical records of 78 patients with metastatic melanoma harboring
c-Kit mutations or amplifications. These patients were treated with imatinib at a dose of 400 mg/day continuously unless intolerable toxicities or disease progression occurred. Endpoints for exploration included overall
survival (OS), progression-free survival (PFS), objective response rate (ORR), and disease of control rate
(DCR). The median OS and PFS of all patients were 13.1 and 4.2 months,… More >
Open Access
ARTICLE
Liwei Jia*, Dongying Lv†, Shuang Zhang*, Zhenyue Wang*, Bo Zhou*
Oncology Research, Vol.27, No.4, pp. 503-508, 2019, DOI:10.3727/096504018X15344989701565
Abstract Astragaloside IV (AS-IV) is an active ingredient in Astragalus membranaceus and is involved in various
biological processes, such as regulating the immune system, and counteracting inflammation and malignancy.
The aim of this study was to explore the effect of AS-IV on non-small cell lung cancer (NSCLC) cells. Cell
counting kit (CCK)-8 assay and flow cytometry were performed to investigate cell survival and cell death, and
Western blotting was performed to assess protein expression. We found that AS-IV inhibited the migration
and proliferation of NSCLC cells and caused a noticeable increase in cell death. Furthermore, the expression
of Bax, a marker… More >
Open Access
REVIEW
Qiaodong Xu1, Songgang Gu1, Jiahong Liang, Zhihua Lin, Shaodong Zheng, Jiang Yan
Oncology Research, Vol.27, No.4, pp. 509-514, 2019, DOI:10.3727/096504018X15278771272963
Abstract Hepatocellular carcinoma (HCC) is one of the major malignant tumors that lead to death. Chronic hepatitis B
virus infection is an important risk factor for HCC initiation. HBx protein, encoded by the HBV X gene, is a
significant factor that promotes HBV-related HCC, although the exact molecular mechanism remains unclear.
This article summarizes the pathological roles and related mechanisms of HBx in HCC. HBx plays a carcinogenic role by promoting cell proliferation, metastasis, and angiogenesis and inhibiting apoptosis in HCC. A
detailed study of the biological functions of HBx will help to elucidate the mechanism of hepatocarcinogenesis
and lead to… More >
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