@Article{096504018X15228863026239, AUTHOR = {Xiyan Sun, Chao Zhang, Yang Cao, Erbiao Liu}, TITLE = {miR-150 Suppresses Tumor Growth in Melanoma Through Downregulation of MYB}, JOURNAL = {Oncology Research}, VOLUME = {27}, YEAR = {2019}, NUMBER = {3}, PAGES = {317--323}, URL = {http://www.techscience.com/or/v27n3/48594}, ISSN = {1555-3906}, ABSTRACT = {miR-150 has been demonstrated to inhibit tumor progression in various human cancers, including colorectal cancer, ovarian cancer, and thyroid cancer. However, the role of miR-150 in melanoma remains to be determined. In this study, we found that miR-150 was underexpressed in melanoma tissues and cell lines. Through transfection of miR-150 mimics, we found that miR-150 significantly inhibited the proliferation, migration, and invasion of melanoma cells. In mechanism, we found that MYB was a target of miR-150 in melanoma cells. Overexpression of miR-150 significantly inhibited mRNA and protein levels of MYB in melanoma cells. Moreover, there was an inverse correlation between the expression of miR-150 and MYB in melanoma tissues. We also showed that MYB was upregulated in melanoma tissues and cell lines. Through functional experiments, we found that restoration of MYB in miR-150-overexpressed melanoma cells rescued the proliferation, migration, and invasion. Therefore, our findings demonstrated that miR-150 suppressed the proliferation, migration, and invasion of melanoma cell by downregulating MYB.}, DOI = {10.3727/096504018X15228863026239} }