Open Access
ARTICLE
miR-455 Functions as a Tumor Suppressor Through Targeting GATA6 in Colorectal Cancer
Hua Yunqi*1,
Yin Fangrui†1,
Yang Yongyan*, Jin Yunjian*, Zhang Wenhui*, Cao Kun*,
Li Min*, Liu Xianfeng*, Ba Caixia*
* Cancer Biotherapy Center and Oncology Department, Baotou Tumor Hospital, Clinical Oncology of Baotou Medical College,
Baotou, Inner Mongolia, P.R. China
† Department of Central Laboratory, The First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia, P.R. China
Oncology Research 2019, 27(3), 311-316. https://doi.org/10.3727/096504018X15220579006875
Abstract
Emerging evidence indicates that microRNAs (miRNAs) are often aberrantly expressed in human cancers.
Meanwhile, the importance of miRNAs in regulating multiple cellular biological processes has been appreciated. The aim of this study was to investigate the significance of miR-455 and identify its possible mechanism
in regulating colorectal cancer (CRC) progression. We found that the expression of miR-455 was sharply
reduced in CRC tissues and cell lines. Importantly, the low expression of miR-455 was associated with poor
overall survival of CRC patients. Overexpression of miR-455 in CRC cell lines significantly inhibited cell
proliferation and migration in vitro. Moreover, GATA-binding protein 6 (GATA6), whose expression can be
inversely regulated by miR-455 in CRC cell lines, was validated as a direct target of miR-455. Overall, our
results revealed that miR-455 functions as a tumor suppressor, and its downregulation may contribute to CRC
progression. Our study may provide a novel therapeutic target for CRC in the future.
Keywords
Cite This Article
Yunqi, H., Fangrui,
. Y., Yongyan,
. Y., Yunjian, J., Wenhui, Z. et al. (2019). miR-455 Functions as a Tumor Suppressor Through Targeting GATA6 in Colorectal Cancer.
Oncology Research, 27(3), 311–316. https://doi.org/10.3727/096504018X15220579006875