Open Access

ARTICLE

miR-455 Functions as a Tumor Suppressor Through Targeting GATA6 in Colorectal Cancer

Hua Yunqi^*1, Yin Fangrui^†1, Yang Yongyan^*, Jin Yunjian^*, Zhang Wenhui^*, Cao Kun^*, Li Min^*, Liu Xianfeng^*, Ba Caixia^*

* Cancer Biotherapy Center and Oncology Department, Baotou Tumor Hospital, Clinical Oncology of Baotou Medical College, Baotou, Inner Mongolia, P.R. China
† Department of Central Laboratory, The First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia, P.R. China

Oncology Research 2019, 27(3), 311-316. https://doi.org/10.3727/096504018X15220579006875

Abstract

Emerging evidence indicates that microRNAs (miRNAs) are often aberrantly expressed in human cancers. Meanwhile, the importance of miRNAs in regulating multiple cellular biological processes has been appreciated. The aim of this study was to investigate the significance of miR-455 and identify its possible mechanism in regulating colorectal cancer (CRC) progression. We found that the expression of miR-455 was sharply reduced in CRC tissues and cell lines. Importantly, the low expression of miR-455 was associated with poor overall survival of CRC patients. Overexpression of miR-455 in CRC cell lines significantly inhibited cell proliferation and migration in vitro. Moreover, GATA-binding protein 6 (GATA6), whose expression can be inversely regulated by miR-455 in CRC cell lines, was validated as a direct target of miR-455. Overall, our results revealed that miR-455 functions as a tumor suppressor, and its downregulation may contribute to CRC progression. Our study may provide a novel therapeutic target for CRC in the future.

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