Open Access
ARTICLE
miR-188-5p Suppresses Gastric Cancer Cell Proliferation and Invasion via Targeting ZFP91
Yuping Peng, Xuning Shen, Honggang Jiang, Zhiheng Chen, Jiaming Wu, Yi Zhu, Yuan Zhou, Jin Li
Department of Gastrointestinal Surgery, Jiaxing First Hospital, Jiaxing, Zhejiang Province, P.R. China
Oncology Research 2019, 27(1), 65-71. https://doi.org/10.3727/096504018X15191223015016
Abstract
MicroRNAs (miRNAs) have been demonstrated to be essential regulators in the development and progression
of various cancers. The role of miR-188-5p in gastric cancer (GC) has not been determined. In this study, we
found that the expression of miR-188-5p was downregulated in GC tissues compared with adjacent normal tissues. The lowly expressed miR-188-5p was significantly associated with lymph node metastasis and advanced
TNM stage. Moreover, overexpression of miR-188-5p significantly inhibited GC cell proliferation, migration,
and invasion but promoted cellular apoptosis. Mechanistically, we identified transcription factor ZFP91 as a
target gene of miR-188-5p in GC. We found that miR-188-5p overexpression significantly inhibited the expression of ZFP91 in GC cell lines. There was an inverse correlation between the expression of miR-188-5p and
ZFP91 in GC tissues. We found that restoration of ZFP91 in miR-188-5p-overexpressed MGC-803 and SGC-
7901 cells promoted cell proliferation, migration, and invasion. Finally, we also showed that overexpression
of miR-188-5p inhibited tumor growth in vivo. Taken together, our findings indicated that miR-188-5p serves
as a tumor suppressor in human GC by targeting ZFP91, suggesting that miR-188-5p might be a promising
therapeutic target for GC treatment.
Keywords
Cite This Article
Peng, Y., Shen, X., Jiang, H., Chen, Z., Wu, J. et al. (2019). miR-188-5p Suppresses Gastric Cancer Cell Proliferation and Invasion via Targeting ZFP91.
Oncology Research, 27(1), 65–71.