Open Access

ARTICLE

MicroRNA-598 Inhibits Cell Proliferation and Invasion of Glioblastoma by Directly Targeting Metastasis Associated in Colon Cancer-1 (MACC1)

Ning Wang^*1, Yang Zhang^†1, Huaxin Liang^‡

* Department of Neurosurgery, Xiangyang No. 1 People’s Hospital, Hubei University of Medicine, Hubei, P.R. China
† Department of Anesthesiology, Xiangyang No. 1 People’s Hospital, Hubei University of Medicine, Hubei, P.R. China
‡ Department of Neurosurgery, China-Japan Union Hospital, Jilin University, Jilin, P.R. China
1 These authors provided equal contribution to this work

Oncology Research 2018, 26(8), 1275-1283. https://doi.org/10.3727/096504018X15185735627746

Abstract

The dysregulation of microRNA (miRNA) expression is closely related with tumorigenesis and tumor development in glioblastoma (GBM). In this study, we found that miRNA-598 (miR-598) expression was significantly downregulated in GBM tissues and cell lines. Restoring miR-598 expression inhibited cell proliferation and invasion in GBM. Moreover, we validated that metastasis associated in colon cancer-1 (MACC1) is a novel target of miR-598 in GBM. Restoring MACC1 expression reversed the inhibitory effects of miR-598 overexpression on GBM cells. In addition, miR-598 overexpression suppressed Met/ AKT pathway activation in GBM. Our results provided compelling evidence that miR-598 serves tumorsuppressive roles in GBM and that its antioncogenic effects are mediated chiefly through the direct suppression of MACC1 expression and regulation of the Met/AKT signaling pathway. Therefore, miR-598 is a potential target in the treatment of GBM.

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