Open Access

ARTICLE

MicroRNA-338-3p Suppresses Proliferation of Human Liver Cancer Cells by Targeting SphK2

Geqiong Xiao^*, Qiong Wang^*, Bo Li^†, Xiaohui Wu^‡, Hui Liao^*, Yili Ren^*, Ning Ai^†*

* Department of Oncology, ShaoXing Municipal Hospital, Shaoxing, Zhejiang, P.R. China
† Department of Interventional Radiology, The 4th Hospital of Hebei Medical University, Shi Jiazhuang, Hebei, P.R. China
‡ Department of Hepatobiliary Surgery, The 4th Hospital of Hebei Medical University, Shi Jiazhuang, Hebei, P.R. China

Oncology Research 2018, 26(8), 1183-1189. https://doi.org/10.3727/096504018X15151495109394

Abstract

Recent studies have revealed abnormal expression of miRNAs in various tumors. Although microRNA-338-3p (miR-338-3p) plays an important role in many types of tumors, its influence on liver cancer (LC) is unknown. In this study, we found that expression of miR-338-3p was decreased in LC cells and tissues. Colony formation and cell proliferation were suppressed by enhanced expression of miR-338-3p in LC cells. Moreover, miR-338-3p targeted sphingosine kinase 2 (SphK2). Silencing of SphK2 had an identical influence as overexpression of miR-338-3p in LC cells. Overexpression of SphK2 without the 3'-untranslated region remarkably enhanced the growth suppression triggered by miR-338-3p in LC cells. These findings indicate that miR- 338-3p influences the development of LC by targeting SphK2, suggesting that miR-338-3p can be targeted as an innovative therapeutic strategy for LC.

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