Open Access

ARTICLE

Expression and Function of Long Noncoding RNA NONHSAT129183 in Papillary Thyroid Cancer

Jian Ding^*, Fuqing Wang^†, Tiangang Xiang^‡, Meng Qiao^§

* Department of General Surgery, The Fourth People’s Hospital of Ji’nan, Ji’nan, Shandong Province, P.R. China
† Department of Burn and Plastic Surgery, Binzhou People’s Hospital, Binzhou, Shandong Province, P.R. China
‡ Department of General Surgery, The Second People’s Hospital of Dongying, Dongying, Shandong Province, P.R. China
§ Department of Dermatology, Qilu Hospital of Shandong University, Ji’nan, Shandong Province, P.R. China

Oncology Research 2018, 26(7), 1047-1053. https://doi.org/10.3727/096504018X15152037713570

Abstract

The aberrant expression of long noncoding RNAs (lncRNAs) is implicated in cancer development and progression. This study was aimed to investigate the expression and clinical significance of lncRNA NONHSAT129183 in papillary thyroid cancer (PTC), and to explore its roles in PTC cell proliferation, migration, and invasion. Our results demonstrate that lncRNA NONHSAT129183 is upregulated in human PTC tissues when compared with that in adjacent noncancerous thyroid tissue. Moreover, its expression is correlated with tumor size, lymph node metastasis, and TNM stage in PTC patients. lncRNA NONHSAT129183 silencing also significantly suppressed cell proliferation, migration, and invasion in PTC cell lines. In conclusion, our results suggest that lncRNA NONHSAT129183 plays a critical role in the regulation of PTC cell proliferation, migration, and invasion, providing new insights into PTC pathogenesis.

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Keywords

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