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Overexpression of Glypican 5 (GPC5) Inhibits Prostate Cancer Cell Proliferation and Invasion via Suppressing Sp1-Mediated EMT and Activation of Wnt/β-Catenin Signaling

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Department of Pathology, General Hospital of Daqing Oil Field, Daqing, P.R. China

Oncology Research 2018, 26(4), 565-572. https://doi.org/10.3727/096504017X15044461944385

Abstract

Glypican 5 (GPC5) belongs to the family of heparan sulfate proteoglycans (HSPGs). It was initially known as a regulator of growth factors and morphogens. Recently, there have been reports on its correlation with the tumorigenic process in the development of some cancers. However, little is known about its precise role in prostate cancer (PCa). In the present study, we explored the expression pattern and biological functions of GPC5 in PCa cells. Our results showed that GPC5 was lowly expressed in PCa cell lines. Upregulation of GPC5 significantly inhibited PCa cell proliferation and invasion in vitro as well as attenuated tumor growth in vivo. We also found that overexpression of GPC5 inhibited the epithelial–mesenchymal transition (EMT) and Wnt/β-catenin signaling activation, which was mediated by Sp1. Taken together, we suggest GPC5 as a tumor suppressor in PCa and provide promising therapeutic strategies for PCa.

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APA Style
Sun, Y., Xu, K., He, M., Fan, G., Lu, H. (2018). Overexpression of glypican 5 (GPC5) inhibits prostate cancer cell proliferation and invasion via suppressing sp1-mediated EMT and activation of wnt/β-catenin signaling. Oncology Research, 26(4), 565-572. https://doi.org/10.3727/096504017X15044461944385
Vancouver Style
Sun Y, Xu K, He M, Fan G, Lu H. Overexpression of glypican 5 (GPC5) inhibits prostate cancer cell proliferation and invasion via suppressing sp1-mediated EMT and activation of wnt/β-catenin signaling. Oncol Res. 2018;26(4):565-572 https://doi.org/10.3727/096504017X15044461944385
IEEE Style
Y. Sun, K. Xu, M. He, G. Fan, and H. Lu, “Overexpression of Glypican 5 (GPC5) Inhibits Prostate Cancer Cell Proliferation and Invasion via Suppressing Sp1-Mediated EMT and Activation of Wnt/β-Catenin Signaling,” Oncol. Res., vol. 26, no. 4, pp. 565-572, 2018. https://doi.org/10.3727/096504017X15044461944385



cc Copyright © 2018 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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